Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity

Karen J Fairlie-Clarke, Tracey J Lamb, Jean Langhorne, Andrea L Graham, Judith E Allen

Research output: Contribution to journalArticlepeer-review

Abstract

Antibody isotype responses can be useful as indicators of immune bias during infection. In studies of parasite co-infection however, interpretation of immune bias is complicated by the occurrence of cross-reactive antibodies. To confidently attribute shifts in immune bias to the presence of a co-infecting parasite, we suggest practical approaches to account for antibody cross-reactivity. The potential for cross-reactive antibodies to influence disease outcome is also discussed.
Original languageEnglish
Article number6
Number of pages12
JournalBMC Immunology
Volume11
DOIs
Publication statusPublished - 2010

Keywords

  • Animals
  • Antibodies, Helminth
  • Antibodies, Protozoan
  • Antigens, Helminth
  • Carbohydrates
  • Cross Reactions
  • Female
  • Filariasis
  • Filarioidea
  • Glycosylation
  • Malaria
  • Merozoite Surface Protein 1
  • Mice
  • Mice, Inbred BALB C
  • Nippostrongylus
  • Peptide Fragments
  • Periodic Acid
  • Plasmodium chabaudi
  • Strongylida Infections
  • Titrimetry

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