Antibody to the HNK-1 glycoepitope affects fasciculation and axonal pathfinding in the developing posterior lateral line nerve of embryonic zebrafish

T Becker, C G Becker, M Schachner, R R Bernhardt

Research output: Contribution to journalArticlepeer-review

Abstract

The HNK-1 glycoepitope, carried by many cell recognition molecules, is present in the developing posterior lateral line nerve and on other primary axons of zebrafish. To elucidate the function of HNK-1 in vivo, the antibody 412 to HNK-1 was injected into zebrafish embryos at 16 h post fertilization (hpf). The injected antibody bound specifically to axons carrying HNK-1. This treatment selectively affected the growth of either one or both posterior lateral line nerves in 39% of the experimental cases (13 of 33 animals), which was significantly more (P
Original languageEnglish
Pages (from-to)37-49
Number of pages13
JournalMechanisms of Development
Volume109
Issue number1
Publication statusPublished - 2001

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