Antigen-induced non-specific suppressor factor in sheep efferent lymph is prostaglandin E2

John Hopkins, I. McConnell, J Raniwalla

Research output: Contribution to journalArticlepeer-review

Abstract

Efferent lymph from the popliteal node of sheep challenged with antigen was found to suppress the in vitro transformation of sheep peripheral blood lymphocytes to a variety of antigens. The suppressor factor appeared 6-20 hr after challenged of the node and was shown to be prostaglandin E2, probably complexed to albumin.
Original languageEnglish
Pages (from-to)205-12
Number of pages8
JournalImmunology
Volume43
Issue number1
Publication statusPublished - May 1981

Keywords

  • Animals
  • Antigens/immunology
  • Chemical Fractionation
  • Chromatography, Affinity
  • Immunosuppression
  • Lymph/analysis
  • Lymph/immunology
  • Lymphocyte Activation
  • Prostaglandins E/analysis
  • Prostaglandins E/immunology
  • Sheep
  • Tuberculin/immunology

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