Antimicrobial host defence peptides: functions and clinical potential

Neeloffer Mookherjee, Marilyn A. Anderson, Henk P. Haagsman, Donald J. Davidson

Research output: Contribution to journalReview articlepeer-review

Abstract

Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are
naturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host’s immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to design
synthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.
Original languageEnglish
JournalNature Reviews Drug Discovery
DOIs
Publication statusPublished - 27 Feb 2020

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