Antimicrobial host defence peptides: functions and clinical potential

Neeloffer Mookherjee; Marilyn A. Anderson; Henk P. Haagsman; Donald J. Davidson

doi:10.1038/s41573-019-0058-8

Antimicrobial host defence peptides: functions and clinical potential

Neeloffer Mookherjee, Marilyn A. Anderson, Henk P. Haagsman, Donald J. Davidson

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are
naturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host’s immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to design
synthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.

Original language	English
Journal	Nature Reviews Drug Discovery
DOIs	https://doi.org/10.1038/s41573-019-0058-8
Publication status	Published - 27 Feb 2020

Access to Document

10.1038/s41573-019-0058-8

Mookherjee Anderson Haagsman Davidson NRDD 2020 accepted
Author's peer reviewed manuscript as accepted for publication.
Accepted author manuscript, 0.99 MB

http://www.nature.com/articles/s41573-019-0058-8

The Antiviral Potential Of Cathelicidin Against Respiratory Syncytial Virus Infections In Infants
Davidson, D., Boardman, J., Bogaert, D., Cunningham, S., McDougall, C. & Schwarze, J.
UK-based charities
1/02/19 → 30/09/22
Project: Research
Human beta-defensin in Atopic Dermatitis: dissecting the mechanism of a novel, targetable, protection against barrier damage.
Davidson, D., Dorin, J., McHugh, B. & Weller, R.
UK-based charities
1/09/18 → 31/12/21
Project: Research

Cite this

@article{1ec38809e8f246848bbbe908ecb5c66e,

title = "Antimicrobial host defence peptides: functions and clinical potential",

abstract = "Cationic host defence peptides (CHDP), also known as antimicrobial peptides, arenaturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host{\textquoteright}s immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to designsynthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.",

author = "Neeloffer Mookherjee and Anderson, {Marilyn A.} and Haagsman, {Henk P.} and Davidson, {Donald J.}",

year = "2020",

month = feb,

day = "27",

doi = "10.1038/s41573-019-0058-8",

language = "English",

journal = "Nature Reviews Drug Discovery",

issn = "1474-1776",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Antimicrobial host defence peptides: functions and clinical potential

AU - Mookherjee, Neeloffer

AU - Anderson, Marilyn A.

AU - Haagsman, Henk P.

AU - Davidson, Donald J.

PY - 2020/2/27

Y1 - 2020/2/27

N2 - Cationic host defence peptides (CHDP), also known as antimicrobial peptides, arenaturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host’s immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to designsynthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.

AB - Cationic host defence peptides (CHDP), also known as antimicrobial peptides, arenaturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host’s immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to designsynthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.

U2 - 10.1038/s41573-019-0058-8

DO - 10.1038/s41573-019-0058-8

M3 - Review article

SN - 1474-1776

JO - Nature Reviews Drug Discovery

JF - Nature Reviews Drug Discovery

ER -

Antimicrobial host defence peptides: functions and clinical potential

Abstract / Description of output

Access to Document

Fingerprint

Projects

The Antiviral Potential Of Cathelicidin Against Respiratory Syncytial Virus Infections In Infants

Human beta-defensin in Atopic Dermatitis: dissecting the mechanism of a novel, targetable, protection against barrier damage.

Cite this