Antimicrobial Prophylaxis Following Liver Transplantation

Michael J. Williams, Peter C. Hayes

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract / Description of output

There is geographic variation in the frequency of some causative organisms, and the optimal strategy for prophylaxis will depend on both the baseline incidence of infection in the population and the local antimicrobial resistance profiles. Surgical site infections are not uncommon following liver transplantation, occurring in between 9 and 37% of liver transplant recipients in case series in which different antibiotic regimens were used. Invasive fungal infections are a serious complication of immunosuppression following liver transplantation. Infection with Mycobacterium tuberculosis is more frequent following liver transplantation. In addition to administration of antimicrobial drugs, vaccination has been proposed as a strategy to reduce infective complications following liver transplantation. However, it should be noted that immunosuppression may reduce the ability to mount a protective immune response to vaccination. Following liver transplantation, infective complications are common, especially in the first 3 months. Perioperative antibiotics reduce the risk of early bacterial infections, including surgical site infections.

Original languageEnglish
Title of host publicationLiver Transplantation
Subtitle of host publicationClinical Assessment and Management
EditorsJames Neuberger, James Ferguson, Philip N. Newsome, Michael Ronan Lucey
PublisherWiley
Chapter52
Pages469-474
Number of pages6
Edition2nd
ISBN (Electronic)9781119634010
ISBN (Print)9781119633983
DOIs
Publication statusPublished - 19 Apr 2021

Keywords / Materials (for Non-textual outputs)

  • antimicrobial prophylaxis
  • bacterial infections
  • fungal infections
  • liver transplantation
  • Mycobacterium tuberculosis
  • surgical site infections
  • vaccination

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