Antipsychotic drugs

James W. Dear; D. Nicholas Bateman

doi:10.1016/j.mpmed.2015.12.026

Antipsychotic drugs

James W. Dear, D. Nicholas Bateman

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Antipsychotic drugs can be classified by chemical structure and receptor specificity. Older phenothiazine antipsychotics act on a wide range of receptor systems, whereas the newer butyrophenone and atypical drugs are more specific, particularly at dopamine receptors. In overdose, adverse events include acute extrapyramidal reactions, sedation and cardiovascular effects including, potentially, arrhythmias. Phenothiazine antipsychotics often have anticholinergic, antihistamine and α-adrenoceptor antagonist activity, resulting in greater toxicity in overdose.

Original language	English
Pages (from-to)	143-144
Number of pages	2
Journal	Medicine
Volume	44
Issue number	3
Early online date	6 Feb 2016
DOIs	https://doi.org/10.1016/j.mpmed.2015.12.026
Publication status	Published - 1 Mar 2016

Keywords / Materials (for Non-textual outputs)

Antipsychotics
atypical antipsychotics
butyrophenones
phenothiazines
thioxanthenes

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10.1016/j.mpmed.2015.12.026

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title = "Antipsychotic drugs",

abstract = "Antipsychotic drugs can be classified by chemical structure and receptor specificity. Older phenothiazine antipsychotics act on a wide range of receptor systems, whereas the newer butyrophenone and atypical drugs are more specific, particularly at dopamine receptors. In overdose, adverse events include acute extrapyramidal reactions, sedation and cardiovascular effects including, potentially, arrhythmias. Phenothiazine antipsychotics often have anticholinergic, antihistamine and α-adrenoceptor antagonist activity, resulting in greater toxicity in overdose.",

keywords = "Antipsychotics, atypical antipsychotics, butyrophenones, phenothiazines, thioxanthenes",

author = "Dear, {James W.} and Bateman, {D. Nicholas}",

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doi = "10.1016/j.mpmed.2015.12.026",

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pages = "143--144",

journal = "Medicine",

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T1 - Antipsychotic drugs

AU - Dear, James W.

AU - Bateman, D. Nicholas

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Antipsychotic drugs can be classified by chemical structure and receptor specificity. Older phenothiazine antipsychotics act on a wide range of receptor systems, whereas the newer butyrophenone and atypical drugs are more specific, particularly at dopamine receptors. In overdose, adverse events include acute extrapyramidal reactions, sedation and cardiovascular effects including, potentially, arrhythmias. Phenothiazine antipsychotics often have anticholinergic, antihistamine and α-adrenoceptor antagonist activity, resulting in greater toxicity in overdose.

AB - Antipsychotic drugs can be classified by chemical structure and receptor specificity. Older phenothiazine antipsychotics act on a wide range of receptor systems, whereas the newer butyrophenone and atypical drugs are more specific, particularly at dopamine receptors. In overdose, adverse events include acute extrapyramidal reactions, sedation and cardiovascular effects including, potentially, arrhythmias. Phenothiazine antipsychotics often have anticholinergic, antihistamine and α-adrenoceptor antagonist activity, resulting in greater toxicity in overdose.

KW - Antipsychotics

KW - atypical antipsychotics

KW - butyrophenones

KW - phenothiazines

KW - thioxanthenes

UR - http://www.scopus.com/inward/record.url?scp=84960336358&partnerID=8YFLogxK

U2 - 10.1016/j.mpmed.2015.12.026

DO - 10.1016/j.mpmed.2015.12.026

M3 - Article

AN - SCOPUS:84960336358

SN - 1357-3039

VL - 44

SP - 143

EP - 144

JO - Medicine

JF - Medicine

IS - 3

ER -

Antipsychotic drugs

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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