Antisense oligonucleotide targeting of Raf-1: importance of raf-1 mRNA expression levels and raf-1-dependent signaling in determining growth response in ovarian cancer

Peter Mullen; Fiona McPhillips; Kenneth MacLeod; Brett Monia; John F Smyth; Simon P Langdon

Antisense oligonucleotide targeting of Raf-1: importance of raf-1 mRNA expression levels and raf-1-dependent signaling in determining growth response in ovarian cancer

Peter Mullen, Fiona McPhillips, Kenneth MacLeod, Brett Monia, John F Smyth, Simon P Langdon

Research output: Contribution to journal › Article › peer-review

Abstract

We sought to identify determinants of growth response to the Raf-1-targeted antisense oligonucleotide (ASO; ISIS 5132) using a large panel of ovarian cancer cell lines.

Original language	English
Pages (from-to)	2100-8
Number of pages	9
Journal	Clinical Cancer Research
Volume	10
Issue number	6
Publication status	Published - 15 Mar 2004

Keywords / Materials (for Non-textual outputs)

Base Sequence
Cell Cycle
Cell Division
Cell Line, Tumor
Female
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Oligonucleotides, Antisense
Ovarian Neoplasms
Proto-Oncogene Proteins c-raf
RNA, Messenger
Transcription, Genetic

Cite this

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title = "Antisense oligonucleotide targeting of Raf-1: importance of raf-1 mRNA expression levels and raf-1-dependent signaling in determining growth response in ovarian cancer",

abstract = "We sought to identify determinants of growth response to the Raf-1-targeted antisense oligonucleotide (ASO; ISIS 5132) using a large panel of ovarian cancer cell lines.",

keywords = "Base Sequence, Cell Cycle, Cell Division, Cell Line, Tumor, Female, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Oligonucleotides, Antisense, Ovarian Neoplasms, Proto-Oncogene Proteins c-raf, RNA, Messenger, Transcription, Genetic",

author = "Peter Mullen and Fiona McPhillips and Kenneth MacLeod and Brett Monia and Smyth, {John F} and Langdon, {Simon P}",

year = "2004",

month = mar,

day = "15",

language = "English",

volume = "10",

pages = "2100--8",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

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TY - JOUR

T1 - Antisense oligonucleotide targeting of Raf-1

T2 - importance of raf-1 mRNA expression levels and raf-1-dependent signaling in determining growth response in ovarian cancer

AU - Mullen, Peter

AU - McPhillips, Fiona

AU - MacLeod, Kenneth

AU - Monia, Brett

AU - Smyth, John F

AU - Langdon, Simon P

PY - 2004/3/15

Y1 - 2004/3/15

N2 - We sought to identify determinants of growth response to the Raf-1-targeted antisense oligonucleotide (ASO; ISIS 5132) using a large panel of ovarian cancer cell lines.

AB - We sought to identify determinants of growth response to the Raf-1-targeted antisense oligonucleotide (ASO; ISIS 5132) using a large panel of ovarian cancer cell lines.

KW - Base Sequence

KW - Cell Cycle

KW - Cell Division

KW - Cell Line, Tumor

KW - Female

KW - Gene Expression Regulation, Enzymologic

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Oligonucleotides, Antisense

KW - Ovarian Neoplasms

KW - Proto-Oncogene Proteins c-raf

KW - RNA, Messenger

KW - Transcription, Genetic

M3 - Article

C2 - 15041731

SN - 1078-0432

VL - 10

SP - 2100

EP - 2108

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 6

ER -

Antisense oligonucleotide targeting of Raf-1: importance of raf-1 mRNA expression levels and raf-1-dependent signaling in determining growth response in ovarian cancer

Abstract

Keywords / Materials (for Non-textual outputs)

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