Antisense oligonucleotide targeting of Raf-1: importance of raf-1 mRNA expression levels and raf-1-dependent signaling in determining growth response in ovarian cancer

Peter Mullen, Fiona McPhillips, Kenneth MacLeod, Brett Monia, John F Smyth, Simon P Langdon

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We sought to identify determinants of growth response to the Raf-1-targeted antisense oligonucleotide (ASO; ISIS 5132) using a large panel of ovarian cancer cell lines.
Original languageEnglish
Pages (from-to)2100-8
Number of pages9
JournalClinical Cancer Research
Volume10
Issue number6
Publication statusPublished - 15 Mar 2004

Keywords / Materials (for Non-textual outputs)

  • Base Sequence
  • Cell Cycle
  • Cell Division
  • Cell Line, Tumor
  • Female
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Oligonucleotides, Antisense
  • Ovarian Neoplasms
  • Proto-Oncogene Proteins c-raf
  • RNA, Messenger
  • Transcription, Genetic

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