APC mutations in colorectal tumors with mismatch repair deficiency

J Huang, N Papadopoulos, A J McKinley, S M Farrington, L J Curtis, A H Wyllie, S Zheng, J K Willson, S D Markowitz, P Morin, K W Kinzler, B Vogelstein, M G Dunlop

Research output: Contribution to journalArticlepeer-review

Abstract

We have investigated the influence of genetic instability [replication error (RER) phenotype] on APC (adenomatous polyposis coli), a gene thought to initiate colorectal tumorigenesis. The prevalence of APC mutations was similar in RER and non-RER tumors, indicating that both tumor types share this step in neoplastic transformation. However, in a total of 101 sequenced mutations, we noted a substantial excess of APC frameshift mutations in the RER cases (70% in RER tumors versus 47% in non-RER tumors, P
Original languageEnglish
Pages (from-to)9049-54
Number of pages6
JournalProceedings of the National Academy of Sciences
Volume93
Issue number17
Publication statusPublished - 20 Aug 1996

Keywords

  • Adenomatous Polyposis Coli
  • Adenomatous Polyposis Coli Protein
  • Base Sequence
  • Cell Transformation, Neoplastic
  • Cytoskeletal Proteins
  • DNA Repair
  • DNA Replication
  • DNA, Satellite
  • Frameshift Mutation
  • Humans
  • Middle Aged
  • Molecular Sequence Data
  • Mutagenesis

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