Abstract
We have investigated the influence of genetic instability [replication error (RER) phenotype] on APC (adenomatous polyposis coli), a gene thought to initiate colorectal tumorigenesis. The prevalence of APC mutations was similar in RER and non-RER tumors, indicating that both tumor types share this step in neoplastic transformation. However, in a total of 101 sequenced mutations, we noted a substantial excess of APC frameshift mutations in the RER cases (70% in RER tumors versus 47% in non-RER tumors, P
Original language | English |
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Pages (from-to) | 9049-54 |
Number of pages | 6 |
Journal | Proceedings of the National Academy of Sciences (PNAS) |
Volume | 93 |
Issue number | 17 |
Publication status | Published - 20 Aug 1996 |
Keywords / Materials (for Non-textual outputs)
- Adenomatous Polyposis Coli
- Adenomatous Polyposis Coli Protein
- Base Sequence
- Cell Transformation, Neoplastic
- Cytoskeletal Proteins
- DNA Repair
- DNA Replication
- DNA, Satellite
- Frameshift Mutation
- Humans
- Middle Aged
- Molecular Sequence Data
- Mutagenesis