APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

Kristiina Rannikmae, Rajesh N Kalaria, Steven M Greenberg, Helena C Chui, Frederick A Schmitt, Neshika Samarasekera, Rustam Al-Shahi Salman, Catherine Sudlow

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebral amyloid angiopathy (CAA) is associated with lobar intracerebral haemorrhage (ICH). While only the ε4 allele of the apolipoprotein E (APOE) gene is associated with the presence of CAA, both APOE-ε4 and ε2 are associated with lobar ICH. The generally accepted explanation is that APOE-ε4 promotes vascular amyloid deposition, while APOE-ε2 promotes progression to severe CAA with associated vasculopathic changes that cause vessel rupture and ICH. We assessed the evidence for these allele-specific effects.
Original languageEnglish
JournalJournal of Neurology, Neurosurgery & Psychiatry
DOIs
Publication statusPublished - 25 Oct 2013

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