APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

Kristiina Rannikmae; Rajesh N Kalaria; Steven M Greenberg; Helena C Chui; Frederick A Schmitt; Neshika Samarasekera; Rustam Al-Shahi Salman; Catherine Sudlow

doi:10.1136/jnnp-2013-306485

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

Kristiina Rannikmae, Rajesh N Kalaria, Steven M Greenberg, Helena C Chui, Frederick A Schmitt, Neshika Samarasekera, Rustam Al-Shahi Salman, Catherine Sudlow

Research output: Contribution to journal › Article › peer-review

Abstract

Cerebral amyloid angiopathy (CAA) is associated with lobar intracerebral haemorrhage (ICH). While only the ε4 allele of the apolipoprotein E (APOE) gene is associated with the presence of CAA, both APOE-ε4 and ε2 are associated with lobar ICH. The generally accepted explanation is that APOE-ε4 promotes vascular amyloid deposition, while APOE-ε2 promotes progression to severe CAA with associated vasculopathic changes that cause vessel rupture and ICH. We assessed the evidence for these allele-specific effects.

Original language	English
Journal	Journal of Neurology, Neurosurgery & Psychiatry
DOIs	https://doi.org/10.1136/jnnp-2013-306485
Publication status	Published - 25 Oct 2013

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10.1136/jnnp-2013-306485

Cerebral Amyloid Angiopathy and intracerebral Haemorrage
Salman, R. (Principal Investigator)
MRC
1/08/11 → 31/01/17
Project: Research
Clinical Research Training F/Ship - Dr Neshika Samarasekera : The contribution of Amloid Angiopathy to Intracerebral Haemorrhage: A Clinico-Radio-Pathological Case-Control Study
Salman, R. (Principal Investigator)
MRC
1/02/10 → 31/01/13
Project: Research

Cite this

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title = "APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis",

abstract = "Cerebral amyloid angiopathy (CAA) is associated with lobar intracerebral haemorrhage (ICH). While only the ε4 allele of the apolipoprotein E (APOE) gene is associated with the presence of CAA, both APOE-ε4 and ε2 are associated with lobar ICH. The generally accepted explanation is that APOE-ε4 promotes vascular amyloid deposition, while APOE-ε2 promotes progression to severe CAA with associated vasculopathic changes that cause vessel rupture and ICH. We assessed the evidence for these allele-specific effects.",

author = "Kristiina Rannikmae and Kalaria, \{Rajesh N\} and Greenberg, \{Steven M\} and Chui, \{Helena C\} and Schmitt, \{Frederick A\} and Neshika Samarasekera and \{Al-Shahi Salman\}, Rustam and Catherine Sudlow",

year = "2013",

month = oct,

day = "25",

doi = "10.1136/jnnp-2013-306485",

language = "English",

journal = "Journal of Neurology, Neurosurgery \& Psychiatry",

issn = "0022-3050",

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TY - JOUR

T1 - APOE associations with severe CAA-associated vasculopathic changes

T2 - collaborative meta-analysis

AU - Rannikmae, Kristiina

AU - Kalaria, Rajesh N

AU - Greenberg, Steven M

AU - Chui, Helena C

AU - Schmitt, Frederick A

AU - Samarasekera, Neshika

AU - Al-Shahi Salman, Rustam

AU - Sudlow, Catherine

PY - 2013/10/25

Y1 - 2013/10/25

N2 - Cerebral amyloid angiopathy (CAA) is associated with lobar intracerebral haemorrhage (ICH). While only the ε4 allele of the apolipoprotein E (APOE) gene is associated with the presence of CAA, both APOE-ε4 and ε2 are associated with lobar ICH. The generally accepted explanation is that APOE-ε4 promotes vascular amyloid deposition, while APOE-ε2 promotes progression to severe CAA with associated vasculopathic changes that cause vessel rupture and ICH. We assessed the evidence for these allele-specific effects.

AB - Cerebral amyloid angiopathy (CAA) is associated with lobar intracerebral haemorrhage (ICH). While only the ε4 allele of the apolipoprotein E (APOE) gene is associated with the presence of CAA, both APOE-ε4 and ε2 are associated with lobar ICH. The generally accepted explanation is that APOE-ε4 promotes vascular amyloid deposition, while APOE-ε2 promotes progression to severe CAA with associated vasculopathic changes that cause vessel rupture and ICH. We assessed the evidence for these allele-specific effects.

U2 - 10.1136/jnnp-2013-306485

DO - 10.1136/jnnp-2013-306485

M3 - Article

C2 - 24163429

SN - 0022-3050

JO - Journal of Neurology, Neurosurgery & Psychiatry

JF - Journal of Neurology, Neurosurgery & Psychiatry

ER -

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

Abstract

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Cerebral Amyloid Angiopathy and intracerebral Haemorrage

Clinical Research Training F/Ship - Dr Neshika Samarasekera : The contribution of Amloid Angiopathy to Intracerebral Haemorrhage: A Clinico-Radio-Pathological Case-Control Study

Cite this