APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds

Donald M. Lyall; Susana Munoz-Maniega; Sarah Harris; Mark Bastin; Catherine Murray; M W Lutz; Ann M Saunders; A D Roses; Maria Valdes Hernandez; Natalie Royle; John Starr; David Porteous; Ian Deary; Joanna Wardlaw

doi:10.1111/ijs.12615

APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds

Donald M. Lyall, Susana Munoz-Maniega, Sarah Harris, Mark Bastin, Catherine Murray, M W Lutz, Ann M Saunders, A D Roses, Maria Valdes Hernandez, Natalie Royle, John Starr, David Porteous, Ian Deary, Joanna Wardlaw

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Background

Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease.

Aim and/or hypothesis

To test for independent associations between two Alzheimer's disease-susceptibility gene loci – APOE ε and the TOMM40 ‘523’ poly-T repeat – and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults.

Methods

Participants in the Lothian Birth Cohort 1936 underwent genotyping for APOE ε and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72·70 years (standard deviation = 0·7; range = 71–74).

Results

No significant effects of APOE ε or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants.

Conclusions

Lack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.

Original language	English
Pages (from-to)	1297-1300
Journal	International Journal of Stroke
Volume	10
Issue number	8
Early online date	26 Aug 2015
DOIs	https://doi.org/10.1111/ijs.12615
Publication status	Published - Dec 2015

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10.1111/ijs.12615

APOE TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds
© 2015 The Authors. International Journal of Stroke published by John Wiley & Sons Ltd on behalf of World Stroke Organization. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 88.6 KBLicence: Creative Commons: Attribution (CC-BY)

http://onlinelibrary.wiley.com/doi/10.1111/ijs.12615/abstract

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A.
1/09/13 → 31/08/19
Project: Research
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I., Bastin, M., Penke, L., Starr, J. & Wardlaw, J.
MRC
8/06/11 → 7/03/15
Project: Research

Cite this

Lyall, D. M., Munoz-Maniega, S., Harris, S., Bastin, M., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Valdes Hernandez, M., Royle, N., Starr, J., Porteous, D., Deary, I., & Wardlaw, J. (2015). APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds. International Journal of Stroke, 10(8), 1297-1300. https://doi.org/10.1111/ijs.12615

@article{1ccabaac931d4689a72cc536ad8bd17f,

title = "APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds",

abstract = "BackgroundTwo markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease.Aim and/or hypothesisTo test for independent associations between two Alzheimer's disease-susceptibility gene loci – APOE ε and the TOMM40 {\textquoteleft}523{\textquoteright} poly-T repeat – and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults.MethodsParticipants in the Lothian Birth Cohort 1936 underwent genotyping for APOE ε and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72·70 years (standard deviation = 0·7; range = 71–74).ResultsNo significant effects of APOE ε or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants.ConclusionsLack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.",

author = "Lyall, {Donald M.} and Susana Munoz-Maniega and Sarah Harris and Mark Bastin and Catherine Murray and Lutz, {M W} and Saunders, {Ann M} and Roses, {A D} and {Valdes Hernandez}, Maria and Natalie Royle and John Starr and David Porteous and Ian Deary and Joanna Wardlaw",

year = "2015",

month = dec,

doi = "10.1111/ijs.12615",

language = "English",

volume = "10",

pages = "1297--1300",

journal = "International Journal of Stroke",

issn = "1747-4930",

publisher = "SAGE Publications",

number = "8",

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TY - JOUR

T1 - APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds

AU - Lyall, Donald M.

AU - Munoz-Maniega, Susana

AU - Harris, Sarah

AU - Bastin, Mark

AU - Murray, Catherine

AU - Lutz, M W

AU - Saunders, Ann M

AU - Roses, A D

AU - Valdes Hernandez, Maria

AU - Royle, Natalie

AU - Starr, John

AU - Porteous, David

AU - Deary, Ian

AU - Wardlaw, Joanna

PY - 2015/12

Y1 - 2015/12

N2 - BackgroundTwo markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease.Aim and/or hypothesisTo test for independent associations between two Alzheimer's disease-susceptibility gene loci – APOE ε and the TOMM40 ‘523’ poly-T repeat – and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults.MethodsParticipants in the Lothian Birth Cohort 1936 underwent genotyping for APOE ε and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72·70 years (standard deviation = 0·7; range = 71–74).ResultsNo significant effects of APOE ε or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants.ConclusionsLack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.

AB - BackgroundTwo markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease.Aim and/or hypothesisTo test for independent associations between two Alzheimer's disease-susceptibility gene loci – APOE ε and the TOMM40 ‘523’ poly-T repeat – and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults.MethodsParticipants in the Lothian Birth Cohort 1936 underwent genotyping for APOE ε and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72·70 years (standard deviation = 0·7; range = 71–74).ResultsNo significant effects of APOE ε or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants.ConclusionsLack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.

U2 - 10.1111/ijs.12615

DO - 10.1111/ijs.12615

M3 - Article

SN - 1747-4930

VL - 10

SP - 1297

EP - 1300

JO - International Journal of Stroke

JF - International Journal of Stroke

IS - 8

ER -

APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds

Abstract / Description of output

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Projects

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II

Cite this