Apolipoprotein E genotype, coagulation, and survival following acute stroke

CJ Weir*, MO McCarron, KW Muir, AG Dyker, G. E. Bone, KR Lees, JAR Nicoll

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The authors hypothesized that divergent influences of the APOE epsilon4 allele on ischemic and hemorrhagic stroke survival might result from differences in coagulation profiles. In 49 hemorrhagic stroke patients, epsilon4 carriers had higher partial thromboplastin time ratios (p <0.01) than non-epsilon4 carriers. Among 529 ischemic stroke patients, increasing epsilon4 allele dose was associated with improved survival (p = 0.03) after adjusting for baseline NIH stroke scale (p = 0.00001) and partial thromboplastin time ratio (p = 0.01). Relative anticoagulation does not fully explain the survival advantage in epsilon4-carrying ischemic stroke patients.

Original languageEnglish
Pages (from-to)1097-1100
Number of pages4
JournalNeurology
Volume57
Issue number6
Publication statusPublished - 25 Sep 2001

Keywords

  • INTRACEREBRAL HEMORRHAGE
  • EPSILON-4 ALLELE

Fingerprint

Dive into the research topics of 'Apolipoprotein E genotype, coagulation, and survival following acute stroke'. Together they form a unique fingerprint.

Cite this