Apoptosis and dendritic dysfunction precede prion protein accumulation in 87V scrapie

E Jamieson, M Jeffrey, J W Ironside, J R Fraser

Research output: Contribution to journalArticlepeer-review

Abstract

The sequence of events involved in the neurodegeneration caused by transmissible spongiform encephalopathies (TSEs) is not yet known. Using a murine scrapie model in which neurodegeneration in the hippocampus is restricted to CA2, we show that pyramidal neuron damage and death by an apoptotic mechanism occur early in the incubation period, prior to the appearance of CA2 disease-specific accumulation of PrP and the onset of clinical disease. We suggest that the initial hippocampal pathological event in this model is dendritic dysfunction and activation of an apoptotic pathway rather than PrP accumulation.

Original languageEnglish
Pages (from-to)2147-53
Number of pages7
JournalNeuroreport
Volume12
Issue number10
Publication statusPublished - 20 Jul 2001

Keywords

  • Animals
  • Apoptosis
  • Dendrites
  • Disease Models, Animal
  • Genes, jun
  • Hippocampus
  • Immunohistochemistry
  • Mice
  • PrPSc Proteins
  • Prions
  • Pyramidal Cells
  • Scrapie

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