Apoptosis and DNA methylation

Huan X Meng, James A Hackett, Colm Nestor, Donncha S Dunican, Monika Madej, James P Reddington, Sari Pennings, David J Harrison, Richard R Meehan

Research output: Contribution to journalArticlepeer-review

Abstract

Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can activate apoptotic pathways associated with maintenance of genome integrity. This perspective focuses on the pathways linking DNA methyltransferases and methyl-CpG binding proteins to apoptosis, and includes new bioinformatic analyses to characterize the evolutionary origin of two G/T mismatch-specific thymine DNA glycosylases, MBD4 and TDG.
Original languageEnglish
Pages (from-to)1798-820
Number of pages23
JournalCancers
Volume3
Issue number2
DOIs
Publication statusPublished - 2011

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