Apoptosis in development

P Meier, A Finch, G Evan

Research output: Contribution to journalArticlepeer-review

Abstract

Essential to the construction, maintenance and repair of tissues is the ability to induce suicide of supernumerary, misplaced or damaged cells with high specificity and efficiency. Study of three principal organisms--the nematode, fruitfly and mouse--indicate that cell suicide is implemented through the activation of an evolutionarily conserved molecular programme intrinsic to all metazoan cells. Dysfunctions in the regulation or execution of cell suicide are implicated in a wide range of developmental abnormalities and diseases.
Original languageEnglish
Pages (from-to)796-801
Number of pages6
JournalNature
Volume407
Issue number6805
DOIs
Publication statusPublished - 12 Oct 2000

Keywords

  • Animals
  • Growth
  • Apoptosis
  • Humans
  • Morphogenesis
  • Drosophila melanogaster
  • Caenorhabditis elegans
  • Mice

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