Apoptosis of hepatic stellate cells involvement in resolution of biliary fibrosis and regulation by soluble growth factors: involvement in resolution of biliary fibrosis and regulation by soluble growth factors

R Issa, E Williams, N Trim, T Kendall, M J Arthur, J Reichen, R C Benyon, J P Iredale

Research output: Contribution to journalArticlepeer-review

Abstract

Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix degrading metalloproteinases and their tissue inhibitors, the TIMPs.
Original languageEnglish
Pages (from-to)548-57
Number of pages10
JournalGut
Volume48
Issue number4
DOIs
Publication statusPublished - Apr 2001

Keywords

  • Animals
  • Apoptosis
  • Cell Count
  • Cycloheximide
  • Growth Substances
  • Hepatocytes
  • In Situ Nick-End Labeling
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II
  • Liver Cirrhosis, Biliary
  • Male
  • Platelet-Derived Growth Factor
  • Rats
  • Rats, Sprague-Dawley
  • Transforming Growth Factor beta

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