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Abstract
Apparent diffusion coefficient (ADC) thresholds are used to determine acute stroke lesion volume, but the reliability of this approach and comparability to the volume of the magnetic resonance diffusion-weighted imaging (MR-DWI) hyperintense lesion is unclear. Methods: We prospectively recruited and clinically assessed patients who had experienced acute ischemic stroke and performed DWI less than 24 hours and at 3 to 7 days after stroke. We compared the volume of the manually outlined DW hyperintense lesion (reference standard) with lesion volumes derived from 3 commonly used ADC thresholds: .55 x 10(-3)/mm(2)/second(-1), .65 x 10(-3)/mm(2)/second(-1), and .75 x 10(-3)/mm(2)/second(-1), with and without "editing" of erroneous tissue. We compared the volumes obtained by reference standard, "raw," and "edited" thresholds. Results: Among 33 representative patients, the acute DWI lesion volume was 15,284 mm(3); the median unedited/edited ADC volumes were 52,972/2786 mm(3), 92,707/6,987 mm(3), and 227,681/unmeasureable mm(3) (.55 x 10(-3)/mm(2)/second(-1), .65 x 10(-3)/mm(2)/second(-1), and .75 x 10(-3)/mm(2)/second(-1) thresholds, respectively). Subacute lesions gave similar differences. These differences between edited and unedited diffusion-weighted imaging and ADC volumes were statistically significant. Conclusions: Threshold-derived ADC volumes require substantial manual editing to avoid over-or underestimating the visible DWI lesion and should be used with caution
Original language | English |
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Pages (from-to) | 906-9 |
Number of pages | 4 |
Journal | Journal of Stroke & Cerebrovascular Diseases |
Volume | 22 |
Issue number | 7 |
DOIs | |
Publication status | Published - Oct 2013 |
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Brain and body temperature after acute stroke
Wardlaw, J. (Principal Investigator), Dennis, M. (Co-investigator) & Marshall, I. (Co-investigator)
1/09/07 → 30/11/10
Project: Research