Appearance of phloridzin-sensitive glucose transport is not controlled at mRNA level in rabbit jejunal enterocytes

M W Smith, A Turvey, T C Freeman

Research output: Contribution to journalArticlepeer-review

Abstract

Glucose uptake by rabbit intestine has been shown to be confined to the upper two-thirds of jejunal villi. Inhibition by phloridzin shows most of this transport to take place through the Na(+)-glucose linked transporter (SGLT1). Parallel measurements on the other hand show SGLT1 mRNA expression to increase rapidly as enterocytes reach the crypt-villus junction. Levels of SGLT1 mRNA then remain elevated in all villus enterocytes. These results provide direct evidence that SGLT1-mediated glucose transport is subject to post-transcriptional control.
Original languageEnglish
Pages (from-to)525-8
Number of pages4
JournalExperimental physiology
Volume77
Issue number3
Publication statusPublished - May 1992

Keywords

  • Animals
  • Biological Transport
  • Female
  • Gene Expression
  • Glucose
  • Jejunum
  • Microvilli
  • Monosaccharide Transport Proteins
  • Phlorhizin
  • RNA Processing, Post-Transcriptional
  • Rabbits
  • Transcription, Genetic

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