Approaches towards expression profiling the response to treatment

Andrew H. Sims, John M. S. Bartlett

Research output: Contribution to journalEditorialpeer-review


Over the past 8 years there has been a wealth of breast cancer gene expression studies. The majority of these studies have focused upon characterising a tumour at presentation, before treatment, rather than looking at the effects of treatment on the tumour. More recently, a number of groups have moved from predicting prognosis based upon long-term follow-up to alternative approaches of using expression profiling to measure the effect of treatment on breast tumours and potentially predict response to therapy using either post-treatment samples or both pre-treatment and post-treatment samples. Whilst this provides great potential to further our understanding of the mode of action of treatments and to more accurately select which patients will benefit from a particular treatment, serious issues of experimental design must be considered.

Original languageEnglish
Article number115
Pages (from-to)-
Number of pages2
JournalBreast Cancer Research
Issue number6
Publication statusPublished - 2008


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