Abstract
Social impairment is frequently associated with mitochondrial dysfunction and altered neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it remains unknown whether mitochondrial disruption contributes to social behavioral deficits. Here, we show that Drosophila mutants in the homolog of the human CYFIP1, a gene linked to autism and schizophrenia, exhibit mitochondrial hyperactivity and altered group behavior. We identify the regulation of GABA availability by mitochondrial activity as a biologically relevant mechanism and demonstrate its contribution to social behavior. Specifically, increased mitochondrial activity causes gamma aminobutyric acid (GABA) sequestration in the mitochondria, reducing GABAergic signaling and resulting in social deficits. Pharmacological and genetic manipulation of mitochondrial activity or GABA signaling corrects the observed abnormalities. We identify Aralar as the mitochondrial transporter that sequesters GABA upon increased mitochondrial activity. This study increases our understanding of how mitochondria modulate neuronal homeostasis and social behavior under physiopathological conditions.
Original language | English |
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Article number | e20 |
Pages (from-to) | 1178 - 1197 |
Number of pages | 41 |
Journal | Cell |
Volume | 180 |
Issue number | 6 |
DOIs | |
Publication status | Published - 19 Mar 2020 |
Keywords
- mitochondrial activity
- mitochondrial membrane potential
- GABA
- social group behavior
- Aralar
- CYFIP1
- autism
- schizophrenia
- SLC25A12 (AGC1)
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Douglas Armstrong
- School of Informatics - Personal Chair in Systems Neurobiology
- Institute for Adaptive and Neural Computation
- Edinburgh Neuroscience
- Data Science and Artificial Intelligence
Person: Academic: Research Active