Architecture of secondary lymphoid tissue in sheep experimentally challenged with scrapie

M.L. Davies, L.J. Hopkins, I. McConnell, S. Halliday, F. Houston, N. Hunter

Research output: Contribution to journalArticlepeer-review

Abstract

Scrapie is a transmissible spongiform encephalopathy in which there is an accumulation of the abnormal form of the prion protein, PrP , in the lymphoreticular system and nervous system. There is a particular accumulation of PrP on follicular dendritic cells within the germinal centre of B-cell follicles. Because accumulation of PrP in the nervous system leads to neuronal cell loss we have examined PrP accumulation in the prescapular and mesenteric lymph nodes in relation to lymph node architecture of scrapie-challenged sheep. We demonstrate that an accumulation of PrP in the lymph node fails to result in gross defects in the microanatomy and phenotype of T- and B-cell areas in the lymph nodes.
Original languageEnglish
Pages (from-to)230-236
Number of pages7
JournalImmunology
Volume111
Issue number2
DOIs
Publication statusPublished - 1 Feb 2004

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