Aromatic Heterocycles as Activating Groups for Asymmetric Conjugate Addition Reactions. Enantioselective Copper-Catalyzed Reduction of 2-Alkenylheteroarenes

Leszek Rupnicki, Aakarsh Saxena, Hon Wai Lam

Research output: Contribution to journalArticlepeer-review

Abstract

The versatility of chiral copper hydride catalysis has been demonstrated through development of highly enantioselective 1,4-reductions of 2-alkenytheteroarenes, substrates that have been rarely considered for asymmetric conjugate addition reactions. Both azoles and azines serve as efficient activating groups for this process.

Original languageEnglish
Pages (from-to)10386–10387
Number of pages3
JournalJournal of the American Chemical Society
Volume131
Issue number30
DOIs
Publication statusPublished - 5 Aug 2009

Keywords

  • ALPHA,BETA-UNSATURATED ESTERS
  • MICHAEL ADDITIONS
  • ACID-DERIVATIVES
  • CUH
  • REAGENTS
  • 1,4-REDUCTIONS
  • NITROALKENES
  • COMPLEXES
  • ALKALOIDS
  • NITRILES

Cite this