Arrhythmogenic role of the border between two areas of cardiac cell alignment

Nina Kudryashova, A S Teplenin, Y V Orlova, L V Selina, K Agladze

Research output: Contribution to journalArticlepeer-review

Abstract

The goal of this study is to develop experimental and computational models of the excitation transition between areas of cardiac tissue with different anatomical anisotropy. Alignment of seeded neonatal rat cardiomyocytes was achieved with the aid of guiding polymer (PMGI) nanofibers, and two areas with orthogonal alignment were placed into a contact. It was found that the excitation wave crossing border between the areas with different alignment direction experiences substantial perturbation, up to the complete conduction block. In addition to the experimental study, this effect was analyzed computationally using generic FitzHugh-Nagumo reaction-diffusion model. It was shown that the non-monotonous changes of the excitation wave velocity on this boundary may be explained by the source/sink mismatch. Thus, the border may play pro-arrhythmogenic role.

Original languageEnglish
Pages (from-to)227-34
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume76
Early online date16 Sep 2014
DOIs
Publication statusPublished - 1 Nov 2014
Externally publishedYes

Keywords

  • Animals
  • Anisotropy
  • Cell Shape
  • Cells, Cultured
  • Computer Simulation
  • Diffusion
  • Electrochemical Techniques
  • Heart Block/pathology
  • Heart Conduction System
  • Models, Biological
  • Myocytes, Cardiac/physiology
  • Nanofibers/chemistry
  • Polymers/chemistry
  • Rats
  • Rats, Wistar
  • Surface Properties

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