Artificial selection reveals the role of transcriptional constraints in the maintenance of life history variation

Joel L. Pick, Masaomi Hatakeyama, Kate E. Ihle, Julien Gasparini, Claudy Haussy, Satoshi Ishishita, Yoichi Matsuda, Takashi Yoshimura, Masahiro M. Kanaoka, Rie Shimizu‐inatsugi, Kentaro K. Shimizu, Barbara Tschirren

Research output: Contribution to journalLetterpeer-review

Abstract

The trade-off between reproduction and self-maintenance is a cornerstone of life history theory, yet its proximate underpinnings
are elusive. Here, we used an artificial selection approach to create replicated lines of Japanese quail (Coturnix japonica) that differ
genetically in their reproductive investment. Whole transcriptome sequencing revealed that females from lines selected for high
reproductive output show a consistent upregulation of genes associated with reproduction but a simultaneous downregulation
of immune genes. Concordant phenotypic differences in immune function (i.e., specific antibody response against keyhole limpet
hemocyanin) were observed between the selection lines, even in males who do not provide parental care. Our findings demonstrate
the key role of obligate transcriptional constraints in the maintenance of life history variation. These constraints set fundamental
limits to productivity and health in natural and domestic animal populations.
Original languageEnglish
Pages (from-to)200-211
JournalEvolution Letters
Volume4
Issue number3
DOIs
Publication statusPublished - 7 Apr 2020

Keywords

  • costs of reproduction
  • egg size
  • immune defence
  • life history trade offs
  • maternal care
  • natural selection

Fingerprint

Dive into the research topics of 'Artificial selection reveals the role of transcriptional constraints in the maintenance of life history variation'. Together they form a unique fingerprint.

Cite this