Assessment of hyperpolarized 3He lung MRI for regional evaluation of interventional therapy: a pilot study in pediatric cystic fibrosis

Neil Woodhouse, Jim M Wild, Edwin J R van Beek, Nigel Hoggard, Nicki Barker, Christopher J Taylor

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

PURPOSE: To determine whether regional changes in lung ventilation in a group of pediatric cystic fibrosis (CF) patients following a course of chest physiotherapy could be detected with (3)He MRI.

MATERIALS AND METHODS: The reproducibility of lung ventilation volume measurements obtained with (3)He lung magnetic resonance imaging (MRI) was established in a group of five children with CF age 6-15 years. The same methodology was then used to evaluate whether standard chest physiotherapy (percussion and drainage) had any immediate effect on regional ventilated lung volumes in a further group of nine age-matched CF children (5-15 years).

RESULTS: Global lung ventilation volumes remained the same within the limits of sensitivity derived from the reproducibility study; however, regional lung ventilation was observed to change in most patients after therapy.

CONCLUSION: (3)He MRI can be successfully used in children with CF, and has the sensitivity to detect regional quantitative changes in lung ventilation following chest physiotherapy.

Original languageEnglish
Pages (from-to)981-8
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume30
Issue number5
DOIs
Publication statusPublished - Nov 2009

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Child
  • Cohort Studies
  • Cystic Fibrosis
  • Helium
  • Humans
  • Image Processing, Computer-Assisted
  • Isotopes
  • Lung
  • Magnetic Resonance Imaging
  • Magnetics
  • Oxygen
  • Pilot Projects
  • Pulmonary Ventilation
  • Spirometry

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