Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Yan Dora Zhang; Amber N. Hurson; Haoyu Zhang; Parichoy Pal Choudhury; Douglas F. Easton; Roger L. Milne; Jacques Simard; Per Hall; Kyriaki Michailidou; Joe Dennis; Marjanka K. Schmidt; Jenny Chang-claude; Puya Gharahkhani; David Whiteman; Peter T. Campbell; Michael Hoffmeister; Mark Jenkins; Ulrike Peters; Li Hsu; Stephen B. Gruber; Graham Casey; Stephanie L. Schmit; Tracy A. O’mara; Amanda B. Spurdle; Deborah J. Thompson; Ian Tomlinson; Immaculata De Vivo; Maria Teresa Landi; Matthew H. Law; Mark M. Iles; Florence Demenais; Rajiv Kumar; Stuart Macgregor; D. Timothy Bishop; Sarah V. Ward; Melissa L. Bondy; Richard Houlston; John K. Wiencke; Beatrice Melin; Jill Barnholtz-sloan; Ben Kinnersley; Margaret R. Wrensch; Christopher I. Amos; Rayjean J. Hung; Paul Brennan; James Mckay; Neil E. Caporaso; Sonja I. Berndt; Brenda M. Birmann; Nicola J. Camp; Peter Kraft; Nathaniel Rothman; Susan L. Slager; Andrew Berchuck; Paul D. P. Pharoah; Thomas A. Sellers; Simon A. Gayther; Celeste L. Pearce; Ellen L. Goode; Joellen M. Schildkraut; Kirsten B. Moysich; Laufey T. Amundadottir; Eric J. Jacobs; Alison P. Klein; Gloria M. Petersen; Harvey A. Risch; Rachel Z. Stolzenberg-solomon; Brian M. Wolpin; Donghui Li; Rosalind A. Eeles; Christopher A. Haiman; Zsofia Kote-jarai; Fredrick R. Schumacher; Ali Amin Al Olama; Mark P. Purdue; Ghislaine Scelo; Marlene D. Dalgaard; Mark H. Greene; Tom Grotmol; Peter A. Kanetsky; Katherine A. Mcglynn; Katherine L. Nathanson; Clare Turnbull; Fredrik Wiklund; Stephen J. Chanock; Nilanjan Chatterjee; Montserrat Garcia-closas

doi:10.1038/s41467-020-16483-3

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Yan Dora Zhang, Amber N. Hurson, Haoyu Zhang, Parichoy Pal Choudhury, Douglas F. Easton, Roger L. Milne, Jacques Simard, Per Hall, Kyriaki Michailidou, Joe Dennis, Marjanka K. Schmidt, Jenny Chang-claude, Puya Gharahkhani, David Whiteman, Peter T. Campbell, Michael Hoffmeister, Mark Jenkins, Ulrike Peters, Li Hsu, Stephen B. GruberGraham Casey, Stephanie L. Schmit, Tracy A. O’mara, Amanda B. Spurdle, Deborah J. Thompson, Ian Tomlinson, Immaculata De Vivo, Maria Teresa Landi, Matthew H. Law, Mark M. Iles, Florence Demenais, Rajiv Kumar, Stuart Macgregor, D. Timothy Bishop, Sarah V. Ward, Melissa L. Bondy, Richard Houlston, John K. Wiencke, Beatrice Melin, Jill Barnholtz-sloan, Ben Kinnersley, Margaret R. Wrensch, Christopher I. Amos, Rayjean J. Hung, Paul Brennan, James Mckay, Neil E. Caporaso, Sonja I. Berndt, Brenda M. Birmann, Nicola J. Camp, Peter Kraft, Nathaniel Rothman, Susan L. Slager, Andrew Berchuck, Paul D. P. Pharoah, Thomas A. Sellers, Simon A. Gayther, Celeste L. Pearce, Ellen L. Goode, Joellen M. Schildkraut, Kirsten B. Moysich, Laufey T. Amundadottir, Eric J. Jacobs, Alison P. Klein, Gloria M. Petersen, Harvey A. Risch, Rachel Z. Stolzenberg-solomon, Brian M. Wolpin, Donghui Li, Rosalind A. Eeles, Christopher A. Haiman, Zsofia Kote-jarai, Fredrick R. Schumacher, Ali Amin Al Olama, Mark P. Purdue, Ghislaine Scelo, Marlene D. Dalgaard, Mark H. Greene, Tom Grotmol, Peter A. Kanetsky, Katherine A. Mcglynn, Katherine L. Nathanson, Clare Turnbull, Fredrik Wiklund, Stephen J. Chanock, Nilanjan Chatterjee, Montserrat Garcia-closas

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-16483-3
Publication status	Published - 3 Jul 2020

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Cite this

Zhang, Y. D., Hurson, A. N., Zhang, H., Choudhury, P. P., Easton, D. F., Milne, R. L., Simard, J., Hall, P., Michailidou, K., Dennis, J., Schmidt, M. K., Chang-claude, J., Gharahkhani, P., Whiteman, D., Campbell, P. T., Hoffmeister, M., Jenkins, M., Peters, U., Hsu, L., ... Garcia-closas, M. (2020). Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-16483-3

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title = "Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers",

author = "Zhang, {Yan Dora} and Hurson, {Amber N.} and Haoyu Zhang and Choudhury, {Parichoy Pal} and Easton, {Douglas F.} and Milne, {Roger L.} and Jacques Simard and Per Hall and Kyriaki Michailidou and Joe Dennis and Schmidt, {Marjanka K.} and Jenny Chang-claude and Puya Gharahkhani and David Whiteman and Campbell, {Peter T.} and Michael Hoffmeister and Mark Jenkins and Ulrike Peters and Li Hsu and Gruber, {Stephen B.} and Graham Casey and Schmit, {Stephanie L.} and O{\textquoteright}mara, {Tracy A.} and Spurdle, {Amanda B.} and Thompson, {Deborah J.} and Ian Tomlinson and {De Vivo}, Immaculata and Landi, {Maria Teresa} and Law, {Matthew H.} and Iles, {Mark M.} and Florence Demenais and Rajiv Kumar and Stuart Macgregor and Bishop, {D. Timothy} and Ward, {Sarah V.} and Bondy, {Melissa L.} and Richard Houlston and Wiencke, {John K.} and Beatrice Melin and Jill Barnholtz-sloan and Ben Kinnersley and Wrensch, {Margaret R.} and Amos, {Christopher I.} and Hung, {Rayjean J.} and Paul Brennan and James Mckay and Caporaso, {Neil E.} and Berndt, {Sonja I.} and Birmann, {Brenda M.} and Camp, {Nicola J.} and Peter Kraft and Nathaniel Rothman and Slager, {Susan L.} and Andrew Berchuck and Pharoah, {Paul D. P.} and Sellers, {Thomas A.} and Gayther, {Simon A.} and Pearce, {Celeste L.} and Goode, {Ellen L.} and Schildkraut, {Joellen M.} and Moysich, {Kirsten B.} and Amundadottir, {Laufey T.} and Jacobs, {Eric J.} and Klein, {Alison P.} and Petersen, {Gloria M.} and Risch, {Harvey A.} and Stolzenberg-solomon, {Rachel Z.} and Wolpin, {Brian M.} and Donghui Li and Eeles, {Rosalind A.} and Haiman, {Christopher A.} and Zsofia Kote-jarai and Schumacher, {Fredrick R.} and {Al Olama}, {Ali Amin} and Purdue, {Mark P.} and Ghislaine Scelo and Dalgaard, {Marlene D.} and Greene, {Mark H.} and Tom Grotmol and Kanetsky, {Peter A.} and Mcglynn, {Katherine A.} and Nathanson, {Katherine L.} and Clare Turnbull and Fredrik Wiklund and Chanock, {Stephen J.} and Nilanjan Chatterjee and Montserrat Garcia-closas",

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doi = "10.1038/s41467-020-16483-3",

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Zhang, YD, Hurson, AN, Zhang, H, Choudhury, PP, Easton, DF, Milne, RL, Simard, J, Hall, P, Michailidou, K, Dennis, J, Schmidt, MK, Chang-claude, J, Gharahkhani, P, Whiteman, D, Campbell, PT, Hoffmeister, M, Jenkins, M, Peters, U, Hsu, L, Gruber, SB, Casey, G, Schmit, SL, O’mara, TA, Spurdle, AB, Thompson, DJ, Tomlinson, I, De Vivo, I, Landi, MT, Law, MH, Iles, MM, Demenais, F, Kumar, R, Macgregor, S, Bishop, DT, Ward, SV, Bondy, ML, Houlston, R, Wiencke, JK, Melin, B, Barnholtz-sloan, J, Kinnersley, B, Wrensch, MR, Amos, CI, Hung, RJ, Brennan, P, Mckay, J, Caporaso, NE, Berndt, SI, Birmann, BM, Camp, NJ, Kraft, P, Rothman, N, Slager, SL, Berchuck, A, Pharoah, PDP, Sellers, TA, Gayther, SA, Pearce, CL, Goode, EL, Schildkraut, JM, Moysich, KB, Amundadottir, LT, Jacobs, EJ, Klein, AP, Petersen, GM, Risch, HA, Stolzenberg-solomon, RZ, Wolpin, BM, Li, D, Eeles, RA, Haiman, CA, Kote-jarai, Z, Schumacher, FR, Al Olama, AA, Purdue, MP, Scelo, G, Dalgaard, MD, Greene, MH, Grotmol, T, Kanetsky, PA, Mcglynn, KA, Nathanson, KL, Turnbull, C, Wiklund, F, Chanock, SJ, Chatterjee, N & Garcia-closas, M 2020, 'Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers', Nature Communications, vol. 11, no. 1. https://doi.org/10.1038/s41467-020-16483-3

TY - JOUR

T1 - Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

AU - Zhang, Yan Dora

AU - Hurson, Amber N.

AU - Zhang, Haoyu

AU - Choudhury, Parichoy Pal

AU - Easton, Douglas F.

AU - Milne, Roger L.

AU - Simard, Jacques

AU - Hall, Per

AU - Michailidou, Kyriaki

AU - Dennis, Joe

AU - Schmidt, Marjanka K.

AU - Chang-claude, Jenny

AU - Gharahkhani, Puya

AU - Whiteman, David

AU - Campbell, Peter T.

AU - Hoffmeister, Michael

AU - Jenkins, Mark

AU - Peters, Ulrike

AU - Hsu, Li

AU - Gruber, Stephen B.

AU - Casey, Graham

AU - Schmit, Stephanie L.

AU - O’mara, Tracy A.

AU - Spurdle, Amanda B.

AU - Thompson, Deborah J.

AU - Tomlinson, Ian

AU - De Vivo, Immaculata

AU - Landi, Maria Teresa

AU - Law, Matthew H.

AU - Iles, Mark M.

AU - Demenais, Florence

AU - Kumar, Rajiv

AU - Macgregor, Stuart

AU - Bishop, D. Timothy

AU - Ward, Sarah V.

AU - Bondy, Melissa L.

AU - Houlston, Richard

AU - Wiencke, John K.

AU - Melin, Beatrice

AU - Barnholtz-sloan, Jill

AU - Kinnersley, Ben

AU - Wrensch, Margaret R.

AU - Amos, Christopher I.

AU - Hung, Rayjean J.

AU - Brennan, Paul

AU - Mckay, James

AU - Caporaso, Neil E.

AU - Berndt, Sonja I.

AU - Birmann, Brenda M.

AU - Camp, Nicola J.

AU - Kraft, Peter

AU - Rothman, Nathaniel

AU - Slager, Susan L.

AU - Berchuck, Andrew

AU - Pharoah, Paul D. P.

AU - Sellers, Thomas A.

AU - Gayther, Simon A.

AU - Pearce, Celeste L.

AU - Goode, Ellen L.

AU - Schildkraut, Joellen M.

AU - Moysich, Kirsten B.

AU - Amundadottir, Laufey T.

AU - Jacobs, Eric J.

AU - Klein, Alison P.

AU - Petersen, Gloria M.

AU - Risch, Harvey A.

AU - Stolzenberg-solomon, Rachel Z.

AU - Wolpin, Brian M.

AU - Li, Donghui

AU - Eeles, Rosalind A.

AU - Haiman, Christopher A.

AU - Kote-jarai, Zsofia

AU - Schumacher, Fredrick R.

AU - Al Olama, Ali Amin

AU - Purdue, Mark P.

AU - Scelo, Ghislaine

AU - Dalgaard, Marlene D.

AU - Greene, Mark H.

AU - Grotmol, Tom

AU - Kanetsky, Peter A.

AU - Mcglynn, Katherine A.

AU - Nathanson, Katherine L.

AU - Turnbull, Clare

AU - Wiklund, Fredrik

AU - Chanock, Stephen J.

AU - Chatterjee, Nilanjan

AU - Garcia-closas, Montserrat

PY - 2020/7/3

Y1 - 2020/7/3

U2 - 10.1038/s41467-020-16483-3

DO - 10.1038/s41467-020-16483-3

M3 - Article

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

ER -