Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress

David J Connolly, Ricardo J Soares Magalhaes, Virginia Luis Fuentes, Adrian Boswood, Georgina Cole, Alisdair Boag, Harriet M Syme

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: To determine if serum natriuretic peptide (NP) concentrations could distinguish cardiac from non-cardiac causes of respiratory distress (RD) in cats.

ANIMALS: Seventy-four cats from 1 university hospital were used.

METHODS: Serum NP concentrations were measured in 41 cats with non-cardiac respiratory distress (RD-NC) and compared to 33 cats with RD due to congestive heart failure (RD+CHF) using sandwich enzyme immunoassays (ELISA).

RESULTS: RD-NC cats had lower (P=0.0001) median NT-proANP and NT-proBNP concentrations (614 and 45 fmol/mL, respectively) than RD+CHF cats (1690 and 523 fmol/mL, respectively). The area under the curve was 0.88 and 0.96 for the receiver operating curve analysis of the diagnostic accuracy of NT-proANP and NT-proBNP concentrations to discriminate RD+CHF from RD-NC cats (P=0.036). An optimum cut-off concentration of 986 fmol/mL for NT-proANP and 220 fmol/mL for NT-proBNP accurately discriminated RD-NC from RC+CHF cats with a sensitivity of 93.8% and 93.9% and a specificity of 80.3% and 87.8%, respectively.

CONCLUSIONS: Serum NP concentrations were different in RD+CHF cats compared to RD-NC cats. Evaluation of circulating NP concentrations may be helpful in the initial approach to cats presenting with respiratory distress, particularly if advances in ELISA technology result in a rapid cage-side test.

Original languageEnglish
Pages (from-to)S41-50
JournalJournal of Veterinary Cardiology
Volume11 Suppl 1
DOIs
Publication statusPublished - May 2009
Externally publishedYes

Keywords

  • Animals
  • Atrial Natriuretic Factor
  • Biological Markers
  • Case-Control Studies
  • Cat Diseases
  • Cats
  • Confidence Intervals
  • Diagnosis, Differential
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Heart Failure
  • Male
  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Protein Precursors
  • ROC Curve
  • Respiration Disorders
  • Sensitivity and Specificity

Fingerprint

Dive into the research topics of 'Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress'. Together they form a unique fingerprint.

Cite this