Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress

David J Connolly; Ricardo J Soares Magalhaes; Virginia Luis Fuentes; Adrian Boswood; Georgina Cole; Alisdair Boag; Harriet M Syme

doi:10.1016/j.jvc.2009.03.001

Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress

David J Connolly, Ricardo J Soares Magalhaes, Virginia Luis Fuentes, Adrian Boswood, Georgina Cole, Alisdair Boag, Harriet M Syme

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

OBJECTIVES: To determine if serum natriuretic peptide (NP) concentrations could distinguish cardiac from non-cardiac causes of respiratory distress (RD) in cats.

ANIMALS: Seventy-four cats from 1 university hospital were used.

METHODS: Serum NP concentrations were measured in 41 cats with non-cardiac respiratory distress (RD-NC) and compared to 33 cats with RD due to congestive heart failure (RD+CHF) using sandwich enzyme immunoassays (ELISA).

RESULTS: RD-NC cats had lower (P=0.0001) median NT-proANP and NT-proBNP concentrations (614 and 45 fmol/mL, respectively) than RD+CHF cats (1690 and 523 fmol/mL, respectively). The area under the curve was 0.88 and 0.96 for the receiver operating curve analysis of the diagnostic accuracy of NT-proANP and NT-proBNP concentrations to discriminate RD+CHF from RD-NC cats (P=0.036). An optimum cut-off concentration of 986 fmol/mL for NT-proANP and 220 fmol/mL for NT-proBNP accurately discriminated RD-NC from RC+CHF cats with a sensitivity of 93.8% and 93.9% and a specificity of 80.3% and 87.8%, respectively.

CONCLUSIONS: Serum NP concentrations were different in RD+CHF cats compared to RD-NC cats. Evaluation of circulating NP concentrations may be helpful in the initial approach to cats presenting with respiratory distress, particularly if advances in ELISA technology result in a rapid cage-side test.

Original language	English
Pages (from-to)	S41-50
Journal	Journal of Veterinary Cardiology
Volume	11 Suppl 1
DOIs	https://doi.org/10.1016/j.jvc.2009.03.001
Publication status	Published - May 2009
Externally published	Yes

Keywords / Materials (for Non-textual outputs)

Animals
Atrial Natriuretic Factor
Biological Markers
Case-Control Studies
Cat Diseases
Cats
Confidence Intervals
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Female
Heart Failure
Male
Natriuretic Peptide, Brain
Peptide Fragments
Protein Precursors
ROC Curve
Respiration Disorders
Sensitivity and Specificity

Access to Document

10.1016/j.jvc.2009.03.001

Cite this

Connolly, D. J., Soares Magalhaes, R. J., Fuentes, V. L., Boswood, A., Cole, G., Boag, A., & Syme, H. M. (2009). Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress. Journal of Veterinary Cardiology, 11 Suppl 1, S41-50. https://doi.org/10.1016/j.jvc.2009.03.001

@article{f9d21c3e27ed4ac0a52f58e0c0ba23db,

title = "Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress",

abstract = "OBJECTIVES: To determine if serum natriuretic peptide (NP) concentrations could distinguish cardiac from non-cardiac causes of respiratory distress (RD) in cats.ANIMALS: Seventy-four cats from 1 university hospital were used.METHODS: Serum NP concentrations were measured in 41 cats with non-cardiac respiratory distress (RD-NC) and compared to 33 cats with RD due to congestive heart failure (RD+CHF) using sandwich enzyme immunoassays (ELISA).RESULTS: RD-NC cats had lower (P=0.0001) median NT-proANP and NT-proBNP concentrations (614 and 45 fmol/mL, respectively) than RD+CHF cats (1690 and 523 fmol/mL, respectively). The area under the curve was 0.88 and 0.96 for the receiver operating curve analysis of the diagnostic accuracy of NT-proANP and NT-proBNP concentrations to discriminate RD+CHF from RD-NC cats (P=0.036). An optimum cut-off concentration of 986 fmol/mL for NT-proANP and 220 fmol/mL for NT-proBNP accurately discriminated RD-NC from RC+CHF cats with a sensitivity of 93.8% and 93.9% and a specificity of 80.3% and 87.8%, respectively.CONCLUSIONS: Serum NP concentrations were different in RD+CHF cats compared to RD-NC cats. Evaluation of circulating NP concentrations may be helpful in the initial approach to cats presenting with respiratory distress, particularly if advances in ELISA technology result in a rapid cage-side test.",

keywords = "Animals, Atrial Natriuretic Factor, Biological Markers, Case-Control Studies, Cat Diseases, Cats, Confidence Intervals, Diagnosis, Differential, Enzyme-Linked Immunosorbent Assay, Female, Heart Failure, Male, Natriuretic Peptide, Brain, Peptide Fragments, Protein Precursors, ROC Curve, Respiration Disorders, Sensitivity and Specificity",

author = "Connolly, {David J} and {Soares Magalhaes}, {Ricardo J} and Fuentes, {Virginia Luis} and Adrian Boswood and Georgina Cole and Alisdair Boag and Syme, {Harriet M}",

year = "2009",

month = may,

doi = "10.1016/j.jvc.2009.03.001",

language = "English",

volume = "11 Suppl 1",

pages = "S41--50",

journal = "Journal of Veterinary Cardiology",

issn = "1875-0834",

publisher = "Elsevier",

}

Connolly, DJ, Soares Magalhaes, RJ, Fuentes, VL, Boswood, A, Cole, G, Boag, A & Syme, HM 2009, 'Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress', Journal of Veterinary Cardiology, vol. 11 Suppl 1, pp. S41-50. https://doi.org/10.1016/j.jvc.2009.03.001

Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress. / Connolly, David J; Soares Magalhaes, Ricardo J; Fuentes, Virginia Luis et al.
In: Journal of Veterinary Cardiology, Vol. 11 Suppl 1, 05.2009, p. S41-50.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress

AU - Connolly, David J

AU - Soares Magalhaes, Ricardo J

AU - Fuentes, Virginia Luis

AU - Boswood, Adrian

AU - Cole, Georgina

AU - Boag, Alisdair

AU - Syme, Harriet M

PY - 2009/5

Y1 - 2009/5

N2 - OBJECTIVES: To determine if serum natriuretic peptide (NP) concentrations could distinguish cardiac from non-cardiac causes of respiratory distress (RD) in cats.ANIMALS: Seventy-four cats from 1 university hospital were used.METHODS: Serum NP concentrations were measured in 41 cats with non-cardiac respiratory distress (RD-NC) and compared to 33 cats with RD due to congestive heart failure (RD+CHF) using sandwich enzyme immunoassays (ELISA).RESULTS: RD-NC cats had lower (P=0.0001) median NT-proANP and NT-proBNP concentrations (614 and 45 fmol/mL, respectively) than RD+CHF cats (1690 and 523 fmol/mL, respectively). The area under the curve was 0.88 and 0.96 for the receiver operating curve analysis of the diagnostic accuracy of NT-proANP and NT-proBNP concentrations to discriminate RD+CHF from RD-NC cats (P=0.036). An optimum cut-off concentration of 986 fmol/mL for NT-proANP and 220 fmol/mL for NT-proBNP accurately discriminated RD-NC from RC+CHF cats with a sensitivity of 93.8% and 93.9% and a specificity of 80.3% and 87.8%, respectively.CONCLUSIONS: Serum NP concentrations were different in RD+CHF cats compared to RD-NC cats. Evaluation of circulating NP concentrations may be helpful in the initial approach to cats presenting with respiratory distress, particularly if advances in ELISA technology result in a rapid cage-side test.

AB - OBJECTIVES: To determine if serum natriuretic peptide (NP) concentrations could distinguish cardiac from non-cardiac causes of respiratory distress (RD) in cats.ANIMALS: Seventy-four cats from 1 university hospital were used.METHODS: Serum NP concentrations were measured in 41 cats with non-cardiac respiratory distress (RD-NC) and compared to 33 cats with RD due to congestive heart failure (RD+CHF) using sandwich enzyme immunoassays (ELISA).RESULTS: RD-NC cats had lower (P=0.0001) median NT-proANP and NT-proBNP concentrations (614 and 45 fmol/mL, respectively) than RD+CHF cats (1690 and 523 fmol/mL, respectively). The area under the curve was 0.88 and 0.96 for the receiver operating curve analysis of the diagnostic accuracy of NT-proANP and NT-proBNP concentrations to discriminate RD+CHF from RD-NC cats (P=0.036). An optimum cut-off concentration of 986 fmol/mL for NT-proANP and 220 fmol/mL for NT-proBNP accurately discriminated RD-NC from RC+CHF cats with a sensitivity of 93.8% and 93.9% and a specificity of 80.3% and 87.8%, respectively.CONCLUSIONS: Serum NP concentrations were different in RD+CHF cats compared to RD-NC cats. Evaluation of circulating NP concentrations may be helpful in the initial approach to cats presenting with respiratory distress, particularly if advances in ELISA technology result in a rapid cage-side test.

KW - Animals

KW - Atrial Natriuretic Factor

KW - Biological Markers

KW - Case-Control Studies

KW - Cat Diseases

KW - Cats

KW - Confidence Intervals

KW - Diagnosis, Differential

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Heart Failure

KW - Male

KW - Natriuretic Peptide, Brain

KW - Peptide Fragments

KW - Protein Precursors

KW - ROC Curve

KW - Respiration Disorders

KW - Sensitivity and Specificity

U2 - 10.1016/j.jvc.2009.03.001

DO - 10.1016/j.jvc.2009.03.001

M3 - Article

C2 - 19394286

SN - 1875-0834

VL - 11 Suppl 1

SP - S41-50

JO - Journal of Veterinary Cardiology

JF - Journal of Veterinary Cardiology

ER -

Assessment of the diagnostic accuracy of circulating natriuretic peptide concentrations to distinguish between cats with cardiac and non-cardiac causes of respiratory distress

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Keywords / Materials (for Non-textual outputs)

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