Association analysis of six candidate genes in a sample of Australian hypertensive patients

P R Huggard, K M Summers, J West, M J West

Research output: Contribution to journalArticlepeer-review

Abstract

1. Essential hypertension is characterized by increased vascular resistance due to narrowing of the small arterioles. This may be influenced by vasoactive substances, cell growth and vascular remodelling. 2. A sample of Australian hypertensive and normotensive subjects was investigated for association with genetic markers which are candidates for a role in blood pressure (BP) regulation due to potential effects on vascular diameter. 3. The six markers used were for genes encoding vasoconstrictors, growth factors and a structural protein of the extracellular matrix. 4. No significant association of any of the markers used was found with BP status in this sample of patients.
Original languageEnglish
Pages (from-to)454-6
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Volume24
Issue number6
Publication statusPublished - 1997

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