Association between anticholinergic burden and dementia in UK Biobank

Jure Mur; Tom Russ; Simon R. Cox; Riccardo E Marioni; GM Terrera

doi:10.1002/trc2.12290

Association between anticholinergic burden and dementia in UK Biobank

Jure Mur, Tom Russ, Simon R. Cox, Riccardo E Marioni, GM Terrera

Research output: Contribution to journal › Article › peer-review

Abstract

Background
Previous studies on the relationship between anticholinergic drugs and dementia have reported heterogeneous results. This variability could be due to different anticholinergic scales and differential effects of distinct classes of drugs.

Methods
Using Cox proportional hazards models, we computed the association between annual anticholinergic burden (AChB) and the risk of dementia in UK Biobank with linked general practitioner prescription records between the years 2000 and 2015 (n = 171,775).

Results
AChB according to most anticholinergic scales (standardized odds ratio range: 1.027–1.125) and the slope of the AChB trajectory (hazard ratio = 1.094; 95% confidence interval: 1.068–1.119) were predictive of dementia. However, the association between AChB and dementia held only for some classes of drugs, especially antidepressants, antiepileptics, and antidiuretics.

Discussion
The heterogeneity in previous findings may partially be due to different effects for different classes of drugs. Future studies should establish differences in more detail and further examine the practicality of a general measure of AChB relating to the risk of dementia.

Original language	English
Article number	e12290
Pages (from-to)	e12290
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	8
Issue number	1
Early online date	12 Apr 2022
DOIs	https://doi.org/10.1002/trc2.12290
Publication status	Published - 2022

Keywords

anticholinergic drugs
cohort study
dementia
prescription drugs
primary care

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Translational Neuroscience: Training The Next Generation Of Basic Neuroscientists To Embrace Clinical Research
Ffrench-Constant, C., Deary, I., Kind, P., Lawrie, S., Price, D., Shipston, M. & Wardlaw, J.
UK-based charities
1/09/17 → 31/08/23
Project: Research

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title = "Association between anticholinergic burden and dementia in UK Biobank",

abstract = "BackgroundPrevious studies on the relationship between anticholinergic drugs and dementia have reported heterogeneous results. This variability could be due to different anticholinergic scales and differential effects of distinct classes of drugs.MethodsUsing Cox proportional hazards models, we computed the association between annual anticholinergic burden (AChB) and the risk of dementia in UK Biobank with linked general practitioner prescription records between the years 2000 and 2015 (n = 171,775).ResultsAChB according to most anticholinergic scales (standardized odds ratio range: 1.027–1.125) and the slope of the AChB trajectory (hazard ratio = 1.094; 95% confidence interval: 1.068–1.119) were predictive of dementia. However, the association between AChB and dementia held only for some classes of drugs, especially antidepressants, antiepileptics, and antidiuretics.DiscussionThe heterogeneity in previous findings may partially be due to different effects for different classes of drugs. Future studies should establish differences in more detail and further examine the practicality of a general measure of AChB relating to the risk of dementia.",

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author = "Jure Mur and Tom Russ and Cox, {Simon R.} and Marioni, {Riccardo E} and GM Terrera",

year = "2022",

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language = "English",

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T1 - Association between anticholinergic burden and dementia in UK Biobank

AU - Mur, Jure

AU - Russ, Tom

AU - Cox, Simon R.

AU - Marioni, Riccardo E

AU - Terrera, GM

PY - 2022

Y1 - 2022

N2 - BackgroundPrevious studies on the relationship between anticholinergic drugs and dementia have reported heterogeneous results. This variability could be due to different anticholinergic scales and differential effects of distinct classes of drugs.MethodsUsing Cox proportional hazards models, we computed the association between annual anticholinergic burden (AChB) and the risk of dementia in UK Biobank with linked general practitioner prescription records between the years 2000 and 2015 (n = 171,775).ResultsAChB according to most anticholinergic scales (standardized odds ratio range: 1.027–1.125) and the slope of the AChB trajectory (hazard ratio = 1.094; 95% confidence interval: 1.068–1.119) were predictive of dementia. However, the association between AChB and dementia held only for some classes of drugs, especially antidepressants, antiepileptics, and antidiuretics.DiscussionThe heterogeneity in previous findings may partially be due to different effects for different classes of drugs. Future studies should establish differences in more detail and further examine the practicality of a general measure of AChB relating to the risk of dementia.

AB - BackgroundPrevious studies on the relationship between anticholinergic drugs and dementia have reported heterogeneous results. This variability could be due to different anticholinergic scales and differential effects of distinct classes of drugs.MethodsUsing Cox proportional hazards models, we computed the association between annual anticholinergic burden (AChB) and the risk of dementia in UK Biobank with linked general practitioner prescription records between the years 2000 and 2015 (n = 171,775).ResultsAChB according to most anticholinergic scales (standardized odds ratio range: 1.027–1.125) and the slope of the AChB trajectory (hazard ratio = 1.094; 95% confidence interval: 1.068–1.119) were predictive of dementia. However, the association between AChB and dementia held only for some classes of drugs, especially antidepressants, antiepileptics, and antidiuretics.DiscussionThe heterogeneity in previous findings may partially be due to different effects for different classes of drugs. Future studies should establish differences in more detail and further examine the practicality of a general measure of AChB relating to the risk of dementia.

KW - anticholinergic drugs

KW - cohort study

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KW - primary care

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SN - 2352-8737

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ER -

Association between anticholinergic burden and dementia in UK Biobank

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Keywords

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Translational Neuroscience: Training The Next Generation Of Basic Neuroscientists To Embrace Clinical Research

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