Association between apolipoprotein E genotype and carotid intima-media thickness may suggest a specific effect on large artery atherothrombotic stroke

Lavinia Paternoster, Nahara Anáni Martínez González, Stephanie Lewis, Cathie Sudlow

Research output: Contribution to journalArticlepeer-review

Abstract

Apolipoprotein E genotype (APOE) influences cholesterol levels and ischemic heart disease. Although there is no convincing overall association with ischemic stroke, APOE may influence large artery (atherothrombotic) stroke, for which carotid intima-media thickness (CIMT) is an informative intermediate phenotype. We therefore performed a systematic review and meta-analysis of the association between APOE and CIMT.
Original languageEnglish
Pages (from-to)48-54
Number of pages7
JournalStroke; a journal of cerebral circulation
Volume39
Issue number1
DOIs
Publication statusPublished - 2008

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