Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

EMBRACE, Kelly L Bolton, Georgia Chenevix-Trench, Cindy Goh, Siegal Sadetzki, Susan J Ramus, Beth Y Karlan, Diether Lambrechts, Evelyn Despierre, Daniel Barrowdale, Lesley McGuffog, Sue Healey, Douglas F Easton, Olga Sinilnikova, Javier Benítez, María J García, Susan Neuhausen, Mitchell H Gail, Patricia Hartge, Susan PeockDebra Frost, D Gareth Evans, Rosalind Eeles, Andrew K Godwin, Mary B Daly, Ava Kwong, Edmond S K Ma, Conxi Lázaro, Ignacio Blanco, Marco Montagna, Emma D'Andrea, Maria Ornella Nicoletto, Sharon E Johnatty, Susanne Krüger Kjær, Allan Jensen, Estrid Høgdall, Ellen L Goode, Brooke L Fridley, Jennifer T Loud, Mark H Greene, Phuong L Mai, Angela Chetrit, Flora Lubin, Galit Hirsh-Yechezkel, Gord Glendon, Irene L Andrulis, Amanda E Toland, Leigha Senter, Martin E Gore, Charles Gourley, Caroline O Michie

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.
Original languageEnglish
Pages (from-to)382-90
Number of pages9
JournalJournal of the American Medical Association
Volume307
Issue number4
DOIs
Publication statusPublished - 2012

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