Association between excessive daytime sleepiness and severe hypoglycemia in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

Berit Inkster; Renata L Riha; Liesbeth Van Look; Rachel Williamson; Stela McLachlan; Brian M Frier; Mark W J Strachan; Jackie F Price; Rebecca M Reynolds

doi:10.2337/dc13-0863

Association between excessive daytime sleepiness and severe hypoglycemia in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

Berit Inkster, Renata L Riha, Liesbeth Van Look, Rachel Williamson, Stela McLachlan, Brian M Frier, Mark W J Strachan, Jackie F Price, Rebecca M Reynolds

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Sleep-disordered breathing and sleepiness cause metabolic, cognitive, and behavioral disturbance. Sleep-disordered breathing is common in type 2 diabetes, a condition that requires adherence to complex dietary, behavioral, and drug treatment regimens. Hypoglycemia is an important side effect of treatment, causing physical and psychological harm and limiting ability to achieve optimal glycemic control. We hypothesized that sleep disorder might increase the risk of hypoglycemia through effects on self-management and glucose regulation.

RESEARCH DESIGN AND METHODS: People with type 2 diabetes (n = 898) completed questionnaires to assess sleep-disordered breathing, daytime sleepiness, and occurrence of severe hypoglycemia.

RESULTS: Subjects who scored highly on the Epworth Sleepiness Scale were significantly more likely to have suffered from severe hypoglycemia. This was a significant predictor of severe hypoglycemia in regression analysis including the variables age, sex, duration of diabetes, HbA1c, BMI, and treatment type.

CONCLUSIONS: Daytime sleepiness may be a novel risk factor for hypoglycemia.

Original language	English
Pages (from-to)	4157-9
Number of pages	3
Journal	Diabetes Care
Volume	36
Issue number	12
DOIs	https://doi.org/10.2337/dc13-0863
Publication status	Published - Dec 2013

Keywords

Aged
Blood Glucose
Diabetes Mellitus, Type 2
Disorders of Excessive Somnolence
Female
Follow-Up Studies
Great Britain
Humans
Hypoglycemia
Incidence
Male
Middle Aged
Questionnaires
Risk Factors
Severity of Illness Index

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title = "Association between excessive daytime sleepiness and severe hypoglycemia in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study",

abstract = "OBJECTIVE: Sleep-disordered breathing and sleepiness cause metabolic, cognitive, and behavioral disturbance. Sleep-disordered breathing is common in type 2 diabetes, a condition that requires adherence to complex dietary, behavioral, and drug treatment regimens. Hypoglycemia is an important side effect of treatment, causing physical and psychological harm and limiting ability to achieve optimal glycemic control. We hypothesized that sleep disorder might increase the risk of hypoglycemia through effects on self-management and glucose regulation.RESEARCH DESIGN AND METHODS: People with type 2 diabetes (n = 898) completed questionnaires to assess sleep-disordered breathing, daytime sleepiness, and occurrence of severe hypoglycemia.RESULTS: Subjects who scored highly on the Epworth Sleepiness Scale were significantly more likely to have suffered from severe hypoglycemia. This was a significant predictor of severe hypoglycemia in regression analysis including the variables age, sex, duration of diabetes, HbA1c, BMI, and treatment type.CONCLUSIONS: Daytime sleepiness may be a novel risk factor for hypoglycemia.",

keywords = "Aged, Blood Glucose, Diabetes Mellitus, Type 2, Disorders of Excessive Somnolence, Female, Follow-Up Studies, Great Britain, Humans, Hypoglycemia, Incidence, Male, Middle Aged, Questionnaires, Risk Factors, Severity of Illness Index",

author = "Berit Inkster and Riha, {Renata L} and {Van Look}, Liesbeth and Rachel Williamson and Stela McLachlan and Frier, {Brian M} and Strachan, {Mark W J} and Price, {Jackie F} and Reynolds, {Rebecca M}",

year = "2013",

month = dec,

doi = "10.2337/dc13-0863",

language = "English",

volume = "36",

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journal = "Diabetes Care",

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publisher = "American Diabetes Association Inc.",

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T1 - Association between excessive daytime sleepiness and severe hypoglycemia in people with type 2 diabetes

T2 - the Edinburgh Type 2 Diabetes Study

AU - Inkster, Berit

AU - Riha, Renata L

AU - Van Look, Liesbeth

AU - Williamson, Rachel

AU - McLachlan, Stela

AU - Frier, Brian M

AU - Strachan, Mark W J

AU - Price, Jackie F

AU - Reynolds, Rebecca M

PY - 2013/12

Y1 - 2013/12

N2 - OBJECTIVE: Sleep-disordered breathing and sleepiness cause metabolic, cognitive, and behavioral disturbance. Sleep-disordered breathing is common in type 2 diabetes, a condition that requires adherence to complex dietary, behavioral, and drug treatment regimens. Hypoglycemia is an important side effect of treatment, causing physical and psychological harm and limiting ability to achieve optimal glycemic control. We hypothesized that sleep disorder might increase the risk of hypoglycemia through effects on self-management and glucose regulation.RESEARCH DESIGN AND METHODS: People with type 2 diabetes (n = 898) completed questionnaires to assess sleep-disordered breathing, daytime sleepiness, and occurrence of severe hypoglycemia.RESULTS: Subjects who scored highly on the Epworth Sleepiness Scale were significantly more likely to have suffered from severe hypoglycemia. This was a significant predictor of severe hypoglycemia in regression analysis including the variables age, sex, duration of diabetes, HbA1c, BMI, and treatment type.CONCLUSIONS: Daytime sleepiness may be a novel risk factor for hypoglycemia.

AB - OBJECTIVE: Sleep-disordered breathing and sleepiness cause metabolic, cognitive, and behavioral disturbance. Sleep-disordered breathing is common in type 2 diabetes, a condition that requires adherence to complex dietary, behavioral, and drug treatment regimens. Hypoglycemia is an important side effect of treatment, causing physical and psychological harm and limiting ability to achieve optimal glycemic control. We hypothesized that sleep disorder might increase the risk of hypoglycemia through effects on self-management and glucose regulation.RESEARCH DESIGN AND METHODS: People with type 2 diabetes (n = 898) completed questionnaires to assess sleep-disordered breathing, daytime sleepiness, and occurrence of severe hypoglycemia.RESULTS: Subjects who scored highly on the Epworth Sleepiness Scale were significantly more likely to have suffered from severe hypoglycemia. This was a significant predictor of severe hypoglycemia in regression analysis including the variables age, sex, duration of diabetes, HbA1c, BMI, and treatment type.CONCLUSIONS: Daytime sleepiness may be a novel risk factor for hypoglycemia.

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KW - Blood Glucose

KW - Diabetes Mellitus, Type 2

KW - Disorders of Excessive Somnolence

KW - Female

KW - Follow-Up Studies

KW - Great Britain

KW - Humans

KW - Hypoglycemia

KW - Incidence

KW - Male

KW - Middle Aged

KW - Questionnaires

KW - Risk Factors

KW - Severity of Illness Index

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DO - 10.2337/dc13-0863

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VL - 36

SP - 4157

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JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 12

ER -

Association between excessive daytime sleepiness and severe hypoglycemia in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study

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Keywords

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