Association between long-term exposure to wildfire-related PM2.5 and mortality: A longitudinal analysis of the UK Biobank

Yuan Gao, Wenzhong Huang, Rongbin Xu, Danijela Gasevic, Yanming Liu, Wenhua Yu, Pei Yu, Xu Yue, Guowei Zhou, Yan Zhang, Hong Liu, Jiangning Song, Yuming Guo, Shanshan Li

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Little is known about the associations between long-term exposure to wildfire-related fine particulate matter (PM2.5) and mortality. We aimed to explore theses associations using the data from the UK Biobank cohort. Long-term wildfire-related PM2.5 exposure was defined as the 3-year cumulative concentrations of wildfire-related PM2.5 within a 10-km buffer surrounding the residential address for each individual. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using the time-varying Cox regression model. We included 492,394 participants aged between 38 and 73 years. We found that after adjusting for potential covariates, a 10 μg/m3 increase of wildfire-related PM2.5 exposure was associated with a 0.4% higher risk of all-cause mortality (HR = 1.004 [95% CI: 1.001, 1.006]) and nonaccidental mortality (HR = 1.004 [95% CI: 1.002, 1.006]), and a 0.5% higher risk of neoplasm mortality (HR = 1.005 [95% CI: 1.002, 1.008]). However, no significant associations were observed between wildfire-related PM2.5 exposure and mortality from cardiovascular, respiratory, and mental diseases. Additionally, no significant modification effects of a series of modifiers were observed. Targeted health protection strategies should be adopted in response to wildfire-related PM2.5 exposure, in order to reduce the risk of premature mortality.

Original languageEnglish
Pages (from-to)131779
JournalJournal of Hazardous Materials
Publication statusPublished - 5 Sept 2023

Keywords / Materials (for Non-textual outputs)

  • Humans
  • Adult
  • Middle Aged
  • Aged
  • Air Pollutants/toxicity
  • Wildfires
  • Biological Specimen Banks
  • Cohort Studies
  • Particulate Matter/analysis
  • United Kingdom/epidemiology
  • Environmental Exposure/analysis
  • Air Pollution/adverse effects


Dive into the research topics of 'Association between long-term exposure to wildfire-related PM2.5 and mortality: A longitudinal analysis of the UK Biobank'. Together they form a unique fingerprint.

Cite this