Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder

Judith Allardyce, Ganna Leonenko, Marian Hamshere, Antonio F. Pardiñas, Liz Forty, Sarah Knott, Katherine Gordon-Smith, David Porteous, Caroline Haywood, Arianna Di Florio, Lisa A Jones, Andrew McIntosh, Michael J Owen, Peter A Holmans, James T.R. Walters, Nicholas Craddock, Ian R Jones, Michael C O'Donovan, Valentina Escott-Price

Research output: Contribution to journalArticlepeer-review

Abstract

Question: what is the relationship between schizophrenia related polygenic liability and the occurrence and level of mood-incongruence of psychotic symptoms in bipolar disorder (BD)? Findings: in this case-control study including 4436 BD cases, 4976 schizophrenia cases and 9012 controls, there was an exposure-response gradient of polygenic risk: Schizophrenia > BD with prominent mood-incongruent psychotic features > BD with mood-congruent psychotic features > BD with no psychosis, all differential associations were statistically-significant. Meaning: A gradient of genetic liability across schizophrenia and bipolar disorder, indexed by the occurrence of psychosis and level of mood-incongruence has been shown for the first time.
Original languageEnglish
Number of pages9
JournalJAMA Psychiatry
Early online date22 Nov 2017
DOIs
Publication statusE-pub ahead of print - 22 Nov 2017

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