Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population

P. A. Thomson, N. R. Wray, J. K. Millar, K. L. Evans, S. L. Hellard, A. Condie, W. J. Muir, D. H. Blackwood, D. J. Porteous

Research output: Contribution to journalArticlepeer-review

Abstract

The Translin-associated factor X/Disrupted in Schizophrenia 1 (TRAX/DISC) region was first implicated as a susceptibility locus for schizophrenia by analysis of a large Scottish family in which a t(1;11) translocation cosegregates with schizophrenia, bipolar disorder and recurrent major depression. We now report evidence for association between bipolar disorder and schizophrenia and this locus in the general Scottish population. A systematic study of linkage disequilibrium in a representative sample of the Scottish population was undertaken across the 510 kb of TRAX and DISC1. SNPs representing each haplotype block were selected for case-control association studies of both schizophrenia and bipolar disorder. Significant association with bipolar disorder in women P=0.00026 (P=0.0016 in men and women combined) was detected in a region of DISC1. This same region also showed nominally significant association with schizophrenia in both men and women combined, P=0.0056. Two further regions, one in TRAX and the second in DISC1, showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men and women respectively, P
Original languageEnglish
Pages (from-to)657-68, 616
JournalMolecular Psychiatry
Volume10
Issue number7
Publication statusPublished - 2005

Keywords

  • Bipolar Disorder/epidemiology/*genetics Case-Control Studies DNA-Binding Proteins/*genetics Female Genetic Predisposition to Disease/*genetics Haplotypes Humans Linkage Disequilibrium Male Nerve Tissue Proteins/*genetics Pedigree Polymorphism, Single Nucleotide/genetics Schizophrenia/epidemiology/*genetics Scotland/epidemiology Sex Factors Statistics, Nonparametric

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