Projects per year
Abstract
Background and Purpose
Inflammatory markers may be associated with recurrent vascular events after stroke. We aimed to determine the association between IL-6, C-reactive protein, fibrinogen and white cell count, with recurrent vascular events after stroke, and to compare the association between circulating inflammatory markers with the risk of death from vascular vs nonvascular causes.
Methods
We prospectively recruited patients with acute stroke (n = 817) and followed them for up to 4 years for the occurrence of fatal or nonfatal recurrent stroke, myocardial infarction or fatal vascular events, and death from any cause (n = 159).
Results
The delay to assessment was a median of 10 days. The adjusted incidence of the outcome cluster recurrent stroke, myocardial infarction or vascular death after stroke was significantly higher with higher levels of IL-6 (75(th) to 25(th) percentile hazard ratio, 1.56; 95% CI, 1.37-1.77), C-reactive protein (75(th) to 25(th) percentile hazard ratio, 1.08; 95% CI, 1.04-1.11), and fibrinogen (75(th) to 25(th) percentile hazard ratio, 1.45; 95% CI, 1.24-1.72). The associations between inflammatory markers and death were stronger than with recurrent vascular events. The associations of inflammatory markers with vascular and nonvascular deaths were similar.
Conclusions
Although inflammatory markers were associated with an increased risk of recurrent vascular events and vascular death after stroke, they were also associated with nonvascular causes of death, suggesting that inflammatory markers do not play a causal role specifically in the generation of recurrent vascular events after stroke. Future studies of the prediction of recurrent vascular events after stroke should concentrate on clinical variables or different blood markers.
Original language | English |
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Pages (from-to) | 10-16 |
Number of pages | 7 |
Journal | Stroke |
Volume | 42 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2011 |
Keywords
- inflammation
- prognosis
- stroke
Fingerprint
Dive into the research topics of 'Association of Circulating Inflammatory Markers With Recurrent Vascular Events After Stroke: A Prospective Cohort Study'. Together they form a unique fingerprint.Projects
- 5 Finished
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Targeted treatment for acute stroke: development of prognostic models & decision support tools
Whiteley, W. & Sandercock, P.
1/09/10 → 28/02/16
Project: Research
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SINAPSE - sub budget - Edinburgh
UK central government bodies/local authorities, health and hospital authorities
1/12/09 → 31/12/14
Project: Research
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