Association of diet and left ventricular wall thickness, troponin-I and IGF-1 in cats with subclinical hypertrophic cardiomyopathy

Ingrid van Hoek, Hannah Hodgkiss-Geere, Liz Bode, Julie Hamilton-Elliott, Paul Mõtsküla, Valentina Palermo, Yolanda Martinez-Pereira, Geoff Culshaw, Jeremy Laxalde, Joanna Dukes-McEwan

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract
Background: Cats with subclinical hypertrophic cardiomyopathy (sHCM) have elevated serum insulin levels and serum amyloid A levels correlating with the degree of cardiac hypertrophy. Diet might affect these parameters and other cardiac variables.
Objective: Evaluate the effect of a complete, balanced diet with restricted starch and supplemented with eicosapentanoic acid+docosahexaenoic acid (EPA+DHA) on echocardiographic parameters and cardiac biomarkers in cats with sHCM.
Animals: Forty-four client-owned cats with sHCM.
Methods: A prospective, randomized, double-blind, multicenter study enrolled cats with end-diastole interventricular septum thickness (IVSd) and/or left ventricular wall thickness (LVWd) ≥6 mm. Non-sedated, fasted cats were examined at baseline and after 6 and 12 months of Test (restricted starch and EPA+DHA supplements) (n=23) or Control (unrestricted starch without EPA+DHA supplementation) (n=21) diet. Assessments included auscultation, body weight, body condition score, echocardiography and blood analysis. Linear and generalized mixed models analyzed diet, time and diet*time interactions (5% significance level).
Results: No differences between diet groups were significant for any variable at any timepoint. There were significant decreases in the Test but not Control group in maximum IVSd (P = .031; P = .524), maximum LVWd (P = .022; P = .905) and insulin-like growth factor-1 levels (P = .036; P = .987) after 12 months, and in ultra-sensitive cardiac troponin I (cTnI) (P = .001; P = .745) after 6 months only.
Conclusions and clinical importance: Significant decreases in echocardiographic variables of sHCM, cTnI and IGF-1, were observed in the Test group. Further research is needed to evaluate effects on clinical outcomes.
Original languageEnglish
JournalJournal of Veterinary Internal Medicine
Early online date20 Oct 2020
DOIs
Publication statusE-pub ahead of print - 20 Oct 2020

Keywords

  • cat
  • cardiac hypertrophy
  • hypertrophic obstructive cardiomyopathy
  • insulin/IGF-1 mediated growth

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