Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression

Stylianos Bournazos; Jacob Grinfeld; Karen M Alexander; John T Murchison; William Wallace; Pauline McFarlane; Nikhil Hirani; A John Simpson; Ian Dransfield; Simon P Hart

doi:10.1186/1471-2466-10-51

Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression

Stylianos Bournazos, Jacob Grinfeld, Karen M Alexander, John T Murchison, William Wallace, Pauline McFarlane, Nikhil Hirani, A John Simpson, Ian Dransfield, Simon P Hart

Research output: Contribution to journal › Article › peer-review

Abstract

A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chronic inflammatory diseases. We investigated whether this polymorphism is associated with IPF susceptibility or progression.

Original language	English
Article number	51
Journal	BMC pulmonary medicine
Volume	10
DOIs	https://doi.org/10.1186/1471-2466-10-51
Publication status	Published - 2010

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10.1186/1471-2466-10-51

Bournazos et al 2010
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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title = "Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression",

abstract = "A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chronic inflammatory diseases. We investigated whether this polymorphism is associated with IPF susceptibility or progression.",

author = "Stylianos Bournazos and Jacob Grinfeld and Alexander, {Karen M} and Murchison, {John T} and William Wallace and Pauline McFarlane and Nikhil Hirani and Simpson, {A John} and Ian Dransfield and Hart, {Simon P}",

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AU - Bournazos, Stylianos

AU - Grinfeld, Jacob

AU - Alexander, Karen M

AU - Murchison, John T

AU - Wallace, William

AU - McFarlane, Pauline

AU - Hirani, Nikhil

AU - Simpson, A John

AU - Dransfield, Ian

AU - Hart, Simon P

PY - 2010

Y1 - 2010

N2 - A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chronic inflammatory diseases. We investigated whether this polymorphism is associated with IPF susceptibility or progression.

AB - A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chronic inflammatory diseases. We investigated whether this polymorphism is associated with IPF susceptibility or progression.

U2 - 10.1186/1471-2466-10-51

DO - 10.1186/1471-2466-10-51

M3 - Article

C2 - 20929558

SN - 1471-2466

VL - 10

JO - BMC pulmonary medicine

JF - BMC pulmonary medicine

M1 - 51

ER -

Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression

Abstract

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