Association of Fibrosis With Mortality and Sudden Cardiac Death in Patients With Nonischemic Dilated Cardiomyopathy

Ankur Gulati, Andrew Jabbour, Tevfik F. Ismail, Kaushik Guha, Jahanzaib Khwaja, Sadaf Raza, Kishen Morarji, Tristan D. H. Brown, Nizar A. Ismail, Marc R. Dweck, Elisa Di Pietro, Michael Roughton, Ricardo Wage, Yousef Daryani, Rory O'Hanlon, Mary N. Sheppard, Francisco Alpendurada, Alexander R. Lyon, Stuart A. Cook, Martin R. CowieRavi G. Assomull, Dudley J. Pennell, Sanjay K. Prasad*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Importance Risk stratification of patients with nonischemic dilated cardiomyopathy is primarily based on left ventricular ejection fraction (LVEF). Superior prognostic factors may improve patient selection for implantable cardioverter-defibrillators (ICDs) and other management decisions.

Objective To determine whether myocardial fibrosis (detected by late gadolinium enhancement cardiovascular magnetic resonance [LGE-CMR] imaging) is an independent and incremental predictor of mortality and sudden cardiac death (SCD) in dilated cardiomyopathy.

Design, Setting, and Patients Prospective, longitudinal study of 472 patients with dilated cardiomyopathy referred to a UK center for CMR imaging between November 2000 and December 2008 after presence and extent of midwall replacement fibrosis were determined. Patients were followed up through December 2011.

Main Outcome Measures Primary end point was all-cause mortality. Secondary end points included cardiovascular mortality or cardiac transplantation; an arrhythmic composite of SCD or aborted SCD (appropriate ICD shock, nonfatal ventricular fibrillation, or sustained ventricular tachycardia); and a composite of HF death, HF hospitalization, or cardiac transplantation.

Results Among the 142 patients with midwall fibrosis, there were 38 deaths (26.8%) vs 35 deaths (10.6%) among the 330 patients without fibrosis (hazard ratio [HR], 2.96 [95% CI, 1.87-4.69]; absolute risk difference, 16.2% [95% CI, 8.2%-24.2%]; P

Conclusions and Relevance Assessment of midwall fibrosis with LGE-CMR imaging provided independent prognostic information beyond LVEF in patients with nonischemic dilated cardiomyopathy. The role of LGE-CMR in the risk stratification of dilated cardiomyopathy requires further investigation.

Original languageEnglish
Pages (from-to)896-908
Number of pages13
JournalJournal of the American Medical Association
Volume309
Issue number9
DOIs
Publication statusPublished - 6 Mar 2013

Keywords

  • IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS
  • CARDIOVASCULAR MAGNETIC-RESONANCE
  • MYOCARDIAL FIBROSIS
  • THERAPY
  • RHYTHM SOCIETY
  • TASK-FORCE
  • PREVENTION
  • HEART-FAILURE
  • PRACTICE GUIDELINES
  • RISK STRATIFICATION

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