Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

Clarissa Boschiero, Erika C Jorge, Kerli Ninov, Kátia Nones, Millor Fernandes do Rosário, Luiz Lehmann Coutinho, Mônica Corrêa Ledur, David W Burt, Ana Silvia A M T Moura

Research output: Contribution to journalArticlepeer-review


Two functional and positional candidate genes were selected in a region of chicken chromosome 1 (GGA1), based on their biological roles, and also where several quantitative trait loci (QTL) have been mapped and associated with performance, fatness and carcass traits in chickens. The insulin-like growth factor 1 (IGF1) gene has been associated with several physiological functions related to growth. The lysine (K)-specific demethylase 5A (KDM5A) gene participates in the epigenetic regulation of genes involved with the cell cycle. Our objective was to find associations of selected single-nucleotide polymorphisms (SNPs) in these genes with performance, fatness and carcass traits in 165 F(2) chickens from a resource population. In the IGF1 gene, 17 SNPs were detected, and in the KDM5A gene, nine SNPs were detected. IGF1 SNP c.47673G > A was associated with body weight and haematocrit percentage, and also with feed intake and percentages of abdominal fat and gizzard genotype × sex interactions. KDM5A SNP c.34208C > T genotype × sex interaction affected body weight, feed intake, percentages of abdominal fat (p = 0.0001), carcass, gizzard and haematocrit. A strong association of the diplotype × sex interaction (p 
Original languageEnglish
Pages (from-to)103-112
Number of pages10
JournalJournal of applied genetics
Issue number1
Early online date30 Dec 2012
Publication statusPublished - Feb 2013


  • Adipose Tissue/metabolism
  • Animals
  • Base Sequence
  • Biometry
  • Body Weight/genetics
  • Chickens/anatomy & histology
  • Chickens/genetics
  • Female
  • Genotype
  • Hematocrit
  • Insulin-Like Growth Factor I/genetics
  • Male
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci
  • Retinoblastoma-Binding Protein 2/genetics
  • Sequence Analysis, DNA


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