Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

Clarissa Boschiero; Erika C Jorge; Kerli Ninov; Kátia Nones; Millor Fernandes do Rosário; Luiz Lehmann Coutinho; Mônica Corrêa Ledur; David W Burt; Ana Silvia A M T Moura

doi:10.1007/s13353-012-0129-6

Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

Clarissa Boschiero, Erika C Jorge, Kerli Ninov, Kátia Nones, Millor Fernandes do Rosário, Luiz Lehmann Coutinho, Mônica Corrêa Ledur, David W Burt, Ana Silvia A M T Moura

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Two functional and positional candidate genes were selected in a region of chicken chromosome 1 (GGA1), based on their biological roles, and also where several quantitative trait loci (QTL) have been mapped and associated with performance, fatness and carcass traits in chickens. The insulin-like growth factor 1 (IGF1) gene has been associated with several physiological functions related to growth. The lysine (K)-specific demethylase 5A (KDM5A) gene participates in the epigenetic regulation of genes involved with the cell cycle. Our objective was to find associations of selected single-nucleotide polymorphisms (SNPs) in these genes with performance, fatness and carcass traits in 165 F(2) chickens from a resource population. In the IGF1 gene, 17 SNPs were detected, and in the KDM5A gene, nine SNPs were detected. IGF1 SNP c.47673G > A was associated with body weight and haematocrit percentage, and also with feed intake and percentages of abdominal fat and gizzard genotype × sex interactions. KDM5A SNP c.34208C > T genotype × sex interaction affected body weight, feed intake, percentages of abdominal fat (p = 0.0001), carcass, gizzard and haematocrit. A strong association of the diplotype × sex interaction (p

Original language	English
Pages (from-to)	103-112
Number of pages	10
Journal	Journal of applied genetics
Volume	54
Issue number	1
Early online date	30 Dec 2012
DOIs	https://doi.org/10.1007/s13353-012-0129-6
Publication status	Published - Feb 2013

Keywords

Adipose Tissue/metabolism
Animals
Base Sequence
Biometry
Body Weight/genetics
Chickens/anatomy & histology
Chickens/genetics
Female
Genotype
Hematocrit
Insulin-Like Growth Factor I/genetics
Male
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Retinoblastoma-Binding Protein 2/genetics
Sequence Analysis, DNA

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10.1007/s13353-012-0129-6

Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickensSubmitted manuscript, 407 KB

http://link.springer.com/article/10.1007%2Fs13353-012-0129-6

ISP1: Analysis and prediction in complex animal systems
Tenesa, A., Archibald, A., Beard, P., Bishop, S., Bronsvoort, M., Burt, D., Freeman, T., Haley, C., Hocking, P., Houston, R., Hume, D., Joshi, A., Law, A., Michoel, T., Summers, K., Vernimmen, D., Watson, M., Wiener, P., Wilson, A., Woolliams, J., Ait-Ali, T., Barnett, M., Carlisle, A., Finlayson, H., Haga, I., Karavolos, M., Matika, O., Paterson, T., Paton, B., Pong-Wong, R., Robert, C. & Robertson, G.
BBSRC
1/04/12 → 31/03/17
Project: Research

Cite this

@article{0d5ffd939d8f474f964764d1a1434cdb,

title = "Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens",

abstract = "Two functional and positional candidate genes were selected in a region of chicken chromosome 1 (GGA1), based on their biological roles, and also where several quantitative trait loci (QTL) have been mapped and associated with performance, fatness and carcass traits in chickens. The insulin-like growth factor 1 (IGF1) gene has been associated with several physiological functions related to growth. The lysine (K)-specific demethylase 5A (KDM5A) gene participates in the epigenetic regulation of genes involved with the cell cycle. Our objective was to find associations of selected single-nucleotide polymorphisms (SNPs) in these genes with performance, fatness and carcass traits in 165 F(2) chickens from a resource population. In the IGF1 gene, 17 SNPs were detected, and in the KDM5A gene, nine SNPs were detected. IGF1 SNP c.47673G > A was associated with body weight and haematocrit percentage, and also with feed intake and percentages of abdominal fat and gizzard genotype × sex interactions. KDM5A SNP c.34208C > T genotype × sex interaction affected body weight, feed intake, percentages of abdominal fat (p = 0.0001), carcass, gizzard and haematocrit. A strong association of the diplotype × sex interaction (p ",

keywords = "Adipose Tissue/metabolism, Animals, Base Sequence, Biometry, Body Weight/genetics, Chickens/anatomy & histology, Chickens/genetics, Female, Genotype, Hematocrit, Insulin-Like Growth Factor I/genetics, Male, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Retinoblastoma-Binding Protein 2/genetics, Sequence Analysis, DNA",

author = "Clarissa Boschiero and Jorge, {Erika C} and Kerli Ninov and K{\'a}tia Nones and {do Ros{\'a}rio}, {Millor Fernandes} and Coutinho, {Luiz Lehmann} and Ledur, {M{\^o}nica Corr{\^e}a} and Burt, {David W} and Moura, {Ana Silvia A M T}",

year = "2013",

month = feb,

doi = "10.1007/s13353-012-0129-6",

language = "English",

volume = "54",

pages = "103--112",

journal = "Journal of applied genetics",

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T1 - Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

AU - Boschiero, Clarissa

AU - Jorge, Erika C

AU - Ninov, Kerli

AU - Nones, Kátia

AU - do Rosário, Millor Fernandes

AU - Coutinho, Luiz Lehmann

AU - Ledur, Mônica Corrêa

AU - Burt, David W

AU - Moura, Ana Silvia A M T

PY - 2013/2

Y1 - 2013/2

N2 - Two functional and positional candidate genes were selected in a region of chicken chromosome 1 (GGA1), based on their biological roles, and also where several quantitative trait loci (QTL) have been mapped and associated with performance, fatness and carcass traits in chickens. The insulin-like growth factor 1 (IGF1) gene has been associated with several physiological functions related to growth. The lysine (K)-specific demethylase 5A (KDM5A) gene participates in the epigenetic regulation of genes involved with the cell cycle. Our objective was to find associations of selected single-nucleotide polymorphisms (SNPs) in these genes with performance, fatness and carcass traits in 165 F(2) chickens from a resource population. In the IGF1 gene, 17 SNPs were detected, and in the KDM5A gene, nine SNPs were detected. IGF1 SNP c.47673G > A was associated with body weight and haematocrit percentage, and also with feed intake and percentages of abdominal fat and gizzard genotype × sex interactions. KDM5A SNP c.34208C > T genotype × sex interaction affected body weight, feed intake, percentages of abdominal fat (p = 0.0001), carcass, gizzard and haematocrit. A strong association of the diplotype × sex interaction (p

AB - Two functional and positional candidate genes were selected in a region of chicken chromosome 1 (GGA1), based on their biological roles, and also where several quantitative trait loci (QTL) have been mapped and associated with performance, fatness and carcass traits in chickens. The insulin-like growth factor 1 (IGF1) gene has been associated with several physiological functions related to growth. The lysine (K)-specific demethylase 5A (KDM5A) gene participates in the epigenetic regulation of genes involved with the cell cycle. Our objective was to find associations of selected single-nucleotide polymorphisms (SNPs) in these genes with performance, fatness and carcass traits in 165 F(2) chickens from a resource population. In the IGF1 gene, 17 SNPs were detected, and in the KDM5A gene, nine SNPs were detected. IGF1 SNP c.47673G > A was associated with body weight and haematocrit percentage, and also with feed intake and percentages of abdominal fat and gizzard genotype × sex interactions. KDM5A SNP c.34208C > T genotype × sex interaction affected body weight, feed intake, percentages of abdominal fat (p = 0.0001), carcass, gizzard and haematocrit. A strong association of the diplotype × sex interaction (p

KW - Adipose Tissue/metabolism

KW - Animals

KW - Base Sequence

KW - Biometry

KW - Body Weight/genetics

KW - Chickens/anatomy & histology

KW - Chickens/genetics

KW - Female

KW - Genotype

KW - Hematocrit

KW - Insulin-Like Growth Factor I/genetics

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

KW - Retinoblastoma-Binding Protein 2/genetics

KW - Sequence Analysis, DNA

U2 - 10.1007/s13353-012-0129-6

DO - 10.1007/s13353-012-0129-6

M3 - Article

C2 - 23275255

VL - 54

SP - 103

EP - 112

JO - Journal of applied genetics

JF - Journal of applied genetics

SN - 1234-1983

IS - 1

ER -

Association of IGF1 and KDM5A polymorphisms with performance, fatness and carcass traits in chickens

Abstract

Keywords

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Projects

ISP1: Analysis and prediction in complex animal systems

Cite this