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Abstract
Neighbourhood features have been postulated as key predictors of frailty. However, evidence is mainly limited to cross-sectional studies without indication of long-term impact. We explored how neighbourhood social deprivation (NSD) across the life course is associated with frailty and frailty progression among older Scottish adults. Participants (n=323) were from the Lothian Birth Cohort 1936 with historical measures of NSD in childhood (1936-1955), young adulthood (1956-1975), and mid-to-late adulthood (1976-2014). Frailty was measured five times between the ages of 70 and 82 years using the Frailty Index. Confounder-adjusted life-course models were assessed using a structured modelling approach; associations were estimated for frailty at baseline using linear regression, and for frailty progression using linear mixed-effects models. Accumulation was the most appropriate life-course model for males; greater accumulated NSD was associated with higher frailty at baseline (b=0.017; 95%CI: 0.005-0.029). Among females, mid-to-late adulthood sensitive period was the best-fit life-course model and higher NSD in this period was associated with widening frailty trajectories (b=0.005; 95%CI: 0.0004-0.009). This is the first investigation of the life-course impact of neighbourhood deprivation on frailty in a cohort of older adults. Policies designed to address neighbourhood deprivation and inequalities across the full life course may support healthy ageing.
Original language | English |
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Pages (from-to) | 1856-1866 |
Journal | American Journal of Epidemiology |
Volume | 191 |
Issue number | 11 |
DOIs | |
Publication status | Published - 27 Jul 2022 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Birth Cohort
- Cross-Sectional Studies
- Female
- Frailty
- Humans
- Life Change Events
- Male
- Residence Characteristics
- Young Adult
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Dive into the research topics of 'Association of Life-Course Neighborhood Deprivation With Frailty and Frailty Progression From Ages 70 to 82 Years in the Lothian Birth Cohort 1936'. Together they form a unique fingerprint.Activities
- 1 Invited talk
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Understanding Ageing: the importance of Place (and of salutogenic landscapes)
Catharine Ward Thompson (Invited speaker)
6 Oct 2022Activity: Academic talk or presentation types › Invited talk