Association of MUTYH and colorectal cancer

A Tenesa, H Campbell, R Barnetson, M Porteous, M Dunlop, S M Farrington

Research output: Contribution to journalArticlepeer-review

Abstract

Mutations in the MUTYH gene have been reported to be associated with increased risk of developing colorectal cancer. In this study, we confirmed this association using original data on 928 colorectal cancer cases and 845 healthy controls from Scotland. We then conducted a meta-analysis from published data on the association between mutations at MUTYH and colorectal cancer risk. We show for the first time a small but significant mono-allelic effect with a genotype relative risk (GRR) of 1.27 (95% confidence interval (CI): 1.01-1.61), and confirm and give a more precise estimate of the strong bi-allelic effect with an estimated GRR of 117 (95% CI: 74-184). This study underscores the need for large sample sizes in order to identify small gene effects when the disease allele frequency is low.
Original languageEnglish
Pages (from-to)239-242
JournalBritish Journal of Cancer
Volume95
Issue number2
DOIs
Publication statusPublished - 17 Jul 2006

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