Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients

Ozren Polasek; Grgo Gunjaca; Ivana Kolcic; Lina Zgaga; Snjezana Dzijan; Robert Smolic; Martina Smolic; Jasminka Milas-Ahic; Vatroslav Seric; Josip Galic; Sandra Tucak-Zoric; Antun Tucak; Igor Rudan; Gordan Lauc

doi:10.3325/cmj.2010.51.48

Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients

Ozren Polasek, Grgo Gunjaca, Ivana Kolcic, Lina Zgaga, Snjezana Dzijan, Robert Smolic, Martina Smolic, Jasminka Milas-Ahic, Vatroslav Seric, Josip Galic, Sandra Tucak-Zoric, Antun Tucak, Igor Rudan, Gordan Lauc

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Aim To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.

Methods A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).

Results There was a weak but significant association of all 4 SNPs and nephrolithiasis (P = 0.029 for rs733175; P = 0.006 for rs6449213; P = 0.020 for rs1014290, and P = 0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance.

Conclusion Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.

Original language	English
Pages (from-to)	48-53
Number of pages	6
Journal	Croatian Medical Journal
Volume	51
Issue number	1
DOIs	https://doi.org/10.3325/cmj.2010.51.48
Publication status	Published - Feb 2010

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Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) Study of 145 Patients
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829176/

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title = "Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients",

abstract = "Aim To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.Methods A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).Results There was a weak but significant association of all 4 SNPs and nephrolithiasis (P = 0.029 for rs733175; P = 0.006 for rs6449213; P = 0.020 for rs1014290, and P = 0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance.Conclusion Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.",

author = "Ozren Polasek and Grgo Gunjaca and Ivana Kolcic and Lina Zgaga and Snjezana Dzijan and Robert Smolic and Martina Smolic and Jasminka Milas-Ahic and Vatroslav Seric and Josip Galic and Sandra Tucak-Zoric and Antun Tucak and Igor Rudan and Gordan Lauc",

year = "2010",

month = feb,

doi = "10.3325/cmj.2010.51.48",

language = "English",

volume = "51",

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T1 - Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients

AU - Polasek, Ozren

AU - Gunjaca, Grgo

AU - Kolcic, Ivana

AU - Zgaga, Lina

AU - Dzijan, Snjezana

AU - Smolic, Robert

AU - Smolic, Martina

AU - Milas-Ahic, Jasminka

AU - Seric, Vatroslav

AU - Galic, Josip

AU - Tucak-Zoric, Sandra

AU - Tucak, Antun

AU - Rudan, Igor

AU - Lauc, Gordan

PY - 2010/2

Y1 - 2010/2

N2 - Aim To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.Methods A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).Results There was a weak but significant association of all 4 SNPs and nephrolithiasis (P = 0.029 for rs733175; P = 0.006 for rs6449213; P = 0.020 for rs1014290, and P = 0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance.Conclusion Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.

AB - Aim To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.Methods A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).Results There was a weak but significant association of all 4 SNPs and nephrolithiasis (P = 0.029 for rs733175; P = 0.006 for rs6449213; P = 0.020 for rs1014290, and P = 0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance.Conclusion Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.

U2 - 10.3325/cmj.2010.51.48

DO - 10.3325/cmj.2010.51.48

M3 - Article

SN - 0353-9504

VL - 51

SP - 48

EP - 53

JO - Croatian Medical Journal

JF - Croatian Medical Journal

IS - 1

ER -

Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients

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