Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9): Study of 145 Patients

Ozren Polasek, Grgo Gunjaca, Ivana Kolcic, Lina Zgaga, Snjezana Dzijan, Robert Smolic, Martina Smolic, Jasminka Milas-Ahic, Vatroslav Seric, Josip Galic, Sandra Tucak-Zoric, Antun Tucak, Igor Rudan, Gordan Lauc

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Aim To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.

Methods A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).

Results There was a weak but significant association of all 4 SNPs and nephrolithiasis (P = 0.029 for rs733175; P = 0.006 for rs6449213; P = 0.020 for rs1014290, and P = 0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance.

Conclusion Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalCroatian Medical Journal
Issue number1
Publication statusPublished - Feb 2010


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