Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Wellcome Trust Case Control Consortium; Abbas Dehghan; Qiong Yang; Annette Peters; Saonli Basu; Joshua C Bis; Alicja R Rudnicka; Maryam Kavousi; Ming-Huei Chen; Jens Baumert; Gordon D O Lowe; Barbara McKnight; Weihong Tang; Moniek de Maat; Martin G Larson; Susana Eyhermendy; Wendy L McArdle; Thomas Lumley; James S Pankow; Albert Hofman; Joseph M Massaro; Fernando Rivadeneira; Melanie Kolz; Kent D Taylor; Cornelia M van Duijn; Sekar Kathiresan; Thomas Illig; Yurii S Aulchenko; Kelly A Volcik; Andrew D Johnson; Andre G Uitterlinden; Geoffrey H Tofler; Christian Gieger; Bruce M Psaty; David J Couper; Eric Boerwinkle; Wolfgang Koenig; Christopher J O'Donnell; Jacqueline C Witteman; David P Strachan; Nicholas L Smith; Aaron R Folsom

doi:10.1161/CIRCGENETICS.108.825224

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

Wellcome Trust Case Control Consortium, Abbas Dehghan, Qiong Yang, Annette Peters, Saonli Basu, Joshua C Bis, Alicja R Rudnicka, Maryam Kavousi, Ming-Huei Chen, Jens Baumert, Gordon D O Lowe, Barbara McKnight, Weihong Tang, Moniek de Maat, Martin G Larson, Susana Eyhermendy, Wendy L McArdle, Thomas Lumley, James S Pankow, Albert HofmanJoseph M Massaro, Fernando Rivadeneira, Melanie Kolz, Kent D Taylor, Cornelia M van Duijn, Sekar Kathiresan, Thomas Illig, Yurii S Aulchenko, Kelly A Volcik, Andrew D Johnson, Andre G Uitterlinden, Geoffrey H Tofler, Christian Gieger, Bruce M Psaty, David J Couper, Eric Boerwinkle, Wolfgang Koenig, Christopher J O'Donnell, Jacqueline C Witteman, David P Strachan, Nicholas L Smith, Aaron R Folsom

College of Medicine and Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels.

Original language	English
Pages (from-to)	125-33
Number of pages	9
Journal	Circulation: Cardiovascular Genetics
Volume	2
Issue number	2
DOIs	https://doi.org/10.1161/CIRCGENETICS.108.825224
Publication status	Published - 2009

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10.1161/CIRCGENETICS.108.825224

Association of novel genetic Loci with circulating fibrinogen levels
Published in final edited form as: Circ Cardiovasc Genet. 2009 April ; 2(2): 125–133. doi:10.1161/CIRCGENETICS.108.825224.
Accepted author manuscript, 448 KB

http://circgenetics.ahajournals.org/content/2/2/125

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Wellcome Trust Case Control Consortium, Dehghan, A., Yang, Q., Peters, A., Basu, S., Bis, J. C., Rudnicka, A. R., Kavousi, M., Chen, M.-H., Baumert, J., Lowe, G. D. O., McKnight, B., Tang, W., de Maat, M., Larson, M. G., Eyhermendy, S., McArdle, W. L., Lumley, T., Pankow, J. S., ... Folsom, A. R. (2009). Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circulation: Cardiovascular Genetics, 2(2), 125-33. https://doi.org/10.1161/CIRCGENETICS.108.825224

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title = "Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts",

abstract = "Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels.",

author = "{Wellcome Trust Case Control Consortium} and Abbas Dehghan and Qiong Yang and Annette Peters and Saonli Basu and Bis, {Joshua C} and Rudnicka, {Alicja R} and Maryam Kavousi and Ming-Huei Chen and Jens Baumert and Lowe, {Gordon D O} and Barbara McKnight and Weihong Tang and {de Maat}, Moniek and Larson, {Martin G} and Susana Eyhermendy and McArdle, {Wendy L} and Thomas Lumley and Pankow, {James S} and Albert Hofman and Massaro, {Joseph M} and Fernando Rivadeneira and Melanie Kolz and Taylor, {Kent D} and {van Duijn}, {Cornelia M} and Sekar Kathiresan and Thomas Illig and Aulchenko, {Yurii S} and Volcik, {Kelly A} and Johnson, {Andrew D} and Uitterlinden, {Andre G} and Tofler, {Geoffrey H} and Christian Gieger and Psaty, {Bruce M} and Couper, {David J} and Eric Boerwinkle and Wolfgang Koenig and O'Donnell, {Christopher J} and Witteman, {Jacqueline C} and Strachan, {David P} and Smith, {Nicholas L} and Folsom, {Aaron R}",

year = "2009",

doi = "10.1161/CIRCGENETICS.108.825224",

language = "English",

volume = "2",

pages = "125--33",

journal = "Circulation: Cardiovascular Genetics",

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Wellcome Trust Case Control Consortium, Dehghan, A, Yang, Q, Peters, A, Basu, S, Bis, JC, Rudnicka, AR, Kavousi, M, Chen, M-H, Baumert, J, Lowe, GDO, McKnight, B, Tang, W, de Maat, M, Larson, MG, Eyhermendy, S, McArdle, WL, Lumley, T, Pankow, JS, Hofman, A, Massaro, JM, Rivadeneira, F, Kolz, M, Taylor, KD, van Duijn, CM, Kathiresan, S, Illig, T, Aulchenko, YS, Volcik, KA, Johnson, AD, Uitterlinden, AG, Tofler, GH, Gieger, C, Psaty, BM, Couper, DJ, Boerwinkle, E, Koenig, W, O'Donnell, CJ, Witteman, JC, Strachan, DP, Smith, NL & Folsom, AR 2009, 'Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts', Circulation: Cardiovascular Genetics, vol. 2, no. 2, pp. 125-33. https://doi.org/10.1161/CIRCGENETICS.108.825224

TY - JOUR

T1 - Association of novel genetic Loci with circulating fibrinogen levels

T2 - a genome-wide association study in 6 population-based cohorts

AU - Wellcome Trust Case Control Consortium

AU - Dehghan, Abbas

AU - Yang, Qiong

AU - Peters, Annette

AU - Basu, Saonli

AU - Bis, Joshua C

AU - Rudnicka, Alicja R

AU - Kavousi, Maryam

AU - Chen, Ming-Huei

AU - Baumert, Jens

AU - Lowe, Gordon D O

AU - McKnight, Barbara

AU - Tang, Weihong

AU - de Maat, Moniek

AU - Larson, Martin G

AU - Eyhermendy, Susana

AU - McArdle, Wendy L

AU - Lumley, Thomas

AU - Pankow, James S

AU - Hofman, Albert

AU - Massaro, Joseph M

AU - Rivadeneira, Fernando

AU - Kolz, Melanie

AU - Taylor, Kent D

AU - van Duijn, Cornelia M

AU - Kathiresan, Sekar

AU - Illig, Thomas

AU - Aulchenko, Yurii S

AU - Volcik, Kelly A

AU - Johnson, Andrew D

AU - Uitterlinden, Andre G

AU - Tofler, Geoffrey H

AU - Gieger, Christian

AU - Psaty, Bruce M

AU - Couper, David J

AU - Boerwinkle, Eric

AU - Koenig, Wolfgang

AU - O'Donnell, Christopher J

AU - Witteman, Jacqueline C

AU - Strachan, David P

AU - Smith, Nicholas L

AU - Folsom, Aaron R

PY - 2009

Y1 - 2009

N2 - Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels.

AB - Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels.

U2 - 10.1161/CIRCGENETICS.108.825224

DO - 10.1161/CIRCGENETICS.108.825224

M3 - Article

C2 - 20031576

SN - 1942-3268

VL - 2

SP - 125

EP - 133

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

IS - 2

ER -

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts

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