Projects per year
Abstract / Description of output
Major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BP) are common, disabling and heritable psychiatric diseases with a complex overlapping polygenic architecture. Individuals with these disorders, as well as their unaffected relatives, show widespread structural differences in corticostriatal and limbic networks. Structural variation in many of these brain regions is also heritable and polygenic but whether their genetic architecture overlaps with major psychiatric disorders is unknown. We sought to address this issue by examining the impact of polygenic risk of MDD, SCZ, and BP on subcortical brain volumes and white matter (WM) microstructure in a large single sample of neuroimaging data; the UK Biobank Imaging study. The first release of UK Biobank imaging data compromised participants with overlapping genetic data and subcortical volumes (N = 978) and WM measures (N = 816). The calculation of polygenic risk scores was based on genome-wide association study (GWAS) results generated by the Psychiatric GWAS Consortium (PGC). Our findings however, indicated no statistically significant associations between either subcortical volumes or WM microstructure, and polygenic risk for MDD, SCZ or BP. In the current study, we found little or no evidence for genetic overlap between major psychiatric disorders and structural brain measures. These findings suggest that subcortical brain volumes and WM microstructure may not be closely linked to the genetic mechanisms of major psychiatric disorders.
Original language | English |
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Article number | 42140 |
Journal | Scientific Reports |
Volume | 7 |
Early online date | 10 Feb 2017 |
DOIs | |
Publication status | E-pub ahead of print - 10 Feb 2017 |
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Dive into the research topics of 'Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank'. Together they form a unique fingerprint.Projects
- 1 Finished
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RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
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UK Biobank Public Meeting
Andrew McIntosh (Speaker) & Mark James Adams (Advisor)
7 Oct 2019Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
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Identifying the mechanisms of distress, depression and resilience
Andrew McIntosh (Assessor)
3 Mar 2018 → 4 Mar 2018Activity: Academic talk or presentation types › Invited talk