TY - JOUR
T1 - Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder
AU - Kelmendi, Benjamin
AU - Holsbach-Beltrame, Márcia
AU - McIntosh, Andrew M
AU - Hilt, Lori
AU - George, Elizabeth D
AU - Kitchen, Robert R
AU - Carlyle, Becky C
AU - Pittenger, Christopher
AU - Coric, Vladimir
AU - Nolen-Hoeksema, Susan
AU - Sanacora, Gerard
AU - Simen, Arthur A
N1 - Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Hyperpolarization activated cyclic nucleotide-gated (HCN) potassium channels are implicated in the control of neuronal excitability and are expressed widely in the brain. HCN4 is expressed in brain regions relevant to mood and anxiety disorders including specific thalamic nuclei, the basolateral amygdala, and the midbrain dopamine system. We therefore examined the association of HCN4 with a group of mood and anxiety disorders. We genotyped nine tag SNPs in the HCN4 gene using Sequenom iPLEX Gold technology in 285 Caucasian patients with DSM-IV mood disorders and/or obsessive compulsive disorder and 384 Caucasian controls. HCN4 polymorphisms were analyzed using single marker and haplotype-based association methods. Three SNPs showed nominal association in our population (rs12905211, rs3859014, rs498005). SNP rs12905211 maintained significance after Bonferroni correction, with allele T and haplotype CTC overrepresented in cases. These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; however, these results will require replication using a larger sample.
AB - Hyperpolarization activated cyclic nucleotide-gated (HCN) potassium channels are implicated in the control of neuronal excitability and are expressed widely in the brain. HCN4 is expressed in brain regions relevant to mood and anxiety disorders including specific thalamic nuclei, the basolateral amygdala, and the midbrain dopamine system. We therefore examined the association of HCN4 with a group of mood and anxiety disorders. We genotyped nine tag SNPs in the HCN4 gene using Sequenom iPLEX Gold technology in 285 Caucasian patients with DSM-IV mood disorders and/or obsessive compulsive disorder and 384 Caucasian controls. HCN4 polymorphisms were analyzed using single marker and haplotype-based association methods. Three SNPs showed nominal association in our population (rs12905211, rs3859014, rs498005). SNP rs12905211 maintained significance after Bonferroni correction, with allele T and haplotype CTC overrepresented in cases. These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; however, these results will require replication using a larger sample.
U2 - 10.1016/j.neulet.2011.04.026
DO - 10.1016/j.neulet.2011.04.026
M3 - Article
C2 - 21529705
VL - 496
SP - 195
EP - 199
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -