Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder

Benjamin Kelmendi; Márcia Holsbach-Beltrame; Andrew M McIntosh; Lori Hilt; Elizabeth D George; Robert R Kitchen; Becky C Carlyle; Christopher Pittenger; Vladimir Coric; Susan Nolen-Hoeksema; Gerard Sanacora; Arthur A Simen

doi:10.1016/j.neulet.2011.04.026

Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder

Benjamin Kelmendi, Márcia Holsbach-Beltrame, Andrew M McIntosh, Lori Hilt, Elizabeth D George, Robert R Kitchen, Becky C Carlyle, Christopher Pittenger, Vladimir Coric, Susan Nolen-Hoeksema, Gerard Sanacora, Arthur A Simen

Research output: Contribution to journal › Article › peer-review

Abstract

Hyperpolarization activated cyclic nucleotide-gated (HCN) potassium channels are implicated in the control of neuronal excitability and are expressed widely in the brain. HCN4 is expressed in brain regions relevant to mood and anxiety disorders including specific thalamic nuclei, the basolateral amygdala, and the midbrain dopamine system. We therefore examined the association of HCN4 with a group of mood and anxiety disorders. We genotyped nine tag SNPs in the HCN4 gene using Sequenom iPLEX Gold technology in 285 Caucasian patients with DSM-IV mood disorders and/or obsessive compulsive disorder and 384 Caucasian controls. HCN4 polymorphisms were analyzed using single marker and haplotype-based association methods. Three SNPs showed nominal association in our population (rs12905211, rs3859014, rs498005). SNP rs12905211 maintained significance after Bonferroni correction, with allele T and haplotype CTC overrepresented in cases. These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; however, these results will require replication using a larger sample.

Original language	English
Pages (from-to)	195-9
Number of pages	5
Journal	Neuroscience Letters
Volume	496
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2011.04.026
Publication status	Published - 2011

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10.1016/j.neulet.2011.04.026

Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder
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Kelmendi, Benjamin ; Holsbach-Beltrame, Márcia ; McIntosh, Andrew M ; Hilt, Lori ; George, Elizabeth D ; Kitchen, Robert R ; Carlyle, Becky C ; Pittenger, Christopher ; Coric, Vladimir ; Nolen-Hoeksema, Susan ; Sanacora, Gerard ; Simen, Arthur A. / Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder. In: Neuroscience Letters. 2011 ; Vol. 496, No. 3. pp. 195-9.

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title = "Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder",

abstract = "Hyperpolarization activated cyclic nucleotide-gated (HCN) potassium channels are implicated in the control of neuronal excitability and are expressed widely in the brain. HCN4 is expressed in brain regions relevant to mood and anxiety disorders including specific thalamic nuclei, the basolateral amygdala, and the midbrain dopamine system. We therefore examined the association of HCN4 with a group of mood and anxiety disorders. We genotyped nine tag SNPs in the HCN4 gene using Sequenom iPLEX Gold technology in 285 Caucasian patients with DSM-IV mood disorders and/or obsessive compulsive disorder and 384 Caucasian controls. HCN4 polymorphisms were analyzed using single marker and haplotype-based association methods. Three SNPs showed nominal association in our population (rs12905211, rs3859014, rs498005). SNP rs12905211 maintained significance after Bonferroni correction, with allele T and haplotype CTC overrepresented in cases. These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; however, these results will require replication using a larger sample.",

author = "Benjamin Kelmendi and M{\'a}rcia Holsbach-Beltrame and McIntosh, {Andrew M} and Lori Hilt and George, {Elizabeth D} and Kitchen, {Robert R} and Carlyle, {Becky C} and Christopher Pittenger and Vladimir Coric and Susan Nolen-Hoeksema and Gerard Sanacora and Simen, {Arthur A}",

year = "2011",

doi = "10.1016/j.neulet.2011.04.026",

language = "English",

volume = "496",

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Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder. / Kelmendi, Benjamin; Holsbach-Beltrame, Márcia; McIntosh, Andrew M; Hilt, Lori; George, Elizabeth D; Kitchen, Robert R; Carlyle, Becky C; Pittenger, Christopher; Coric, Vladimir; Nolen-Hoeksema, Susan; Sanacora, Gerard; Simen, Arthur A.

In: Neuroscience Letters, Vol. 496, No. 3, 2011, p. 195-9.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder

AU - Kelmendi, Benjamin

AU - Holsbach-Beltrame, Márcia

AU - McIntosh, Andrew M

AU - Hilt, Lori

AU - George, Elizabeth D

AU - Kitchen, Robert R

AU - Carlyle, Becky C

AU - Pittenger, Christopher

AU - Coric, Vladimir

AU - Nolen-Hoeksema, Susan

AU - Sanacora, Gerard

AU - Simen, Arthur A

PY - 2011

Y1 - 2011

N2 - Hyperpolarization activated cyclic nucleotide-gated (HCN) potassium channels are implicated in the control of neuronal excitability and are expressed widely in the brain. HCN4 is expressed in brain regions relevant to mood and anxiety disorders including specific thalamic nuclei, the basolateral amygdala, and the midbrain dopamine system. We therefore examined the association of HCN4 with a group of mood and anxiety disorders. We genotyped nine tag SNPs in the HCN4 gene using Sequenom iPLEX Gold technology in 285 Caucasian patients with DSM-IV mood disorders and/or obsessive compulsive disorder and 384 Caucasian controls. HCN4 polymorphisms were analyzed using single marker and haplotype-based association methods. Three SNPs showed nominal association in our population (rs12905211, rs3859014, rs498005). SNP rs12905211 maintained significance after Bonferroni correction, with allele T and haplotype CTC overrepresented in cases. These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; however, these results will require replication using a larger sample.

AB - Hyperpolarization activated cyclic nucleotide-gated (HCN) potassium channels are implicated in the control of neuronal excitability and are expressed widely in the brain. HCN4 is expressed in brain regions relevant to mood and anxiety disorders including specific thalamic nuclei, the basolateral amygdala, and the midbrain dopamine system. We therefore examined the association of HCN4 with a group of mood and anxiety disorders. We genotyped nine tag SNPs in the HCN4 gene using Sequenom iPLEX Gold technology in 285 Caucasian patients with DSM-IV mood disorders and/or obsessive compulsive disorder and 384 Caucasian controls. HCN4 polymorphisms were analyzed using single marker and haplotype-based association methods. Three SNPs showed nominal association in our population (rs12905211, rs3859014, rs498005). SNP rs12905211 maintained significance after Bonferroni correction, with allele T and haplotype CTC overrepresented in cases. These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; however, these results will require replication using a larger sample.

U2 - 10.1016/j.neulet.2011.04.026

DO - 10.1016/j.neulet.2011.04.026

M3 - Article

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VL - 496

SP - 195

EP - 199

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -

Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder

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