Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

Wellcome Trust Case Control Consortium 2 (WTCCC2), Kari-Matti Mäkelä, Matthew Traylor, Niku Oksala, Marcus E Kleber, Ilkka Seppälä, Leo-Pekka Lyytikäinen, Jussi A Hernesniemi, Mika Kähönen, Steve Bevan, Peter M Rothwell, Catherine Sudlow, Martin Dichgans, Graciela Delgado, Tanja B Grammer, Hubert Scharnagl, Hugh S Markus, Winfried März, Terho Lehtimäki

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND AND PURPOSE: Patients with genetic background for high circulating oxidized low-density lipoprotein (oxLDL) levels might be at an increased risk of cerebrovascular disease (CVD).

METHODS: The association of oxLDL-variant rs676210 with CVD events was studied in patients undergoing coronary angiography (study A; N = 2913 [271 cases]). We sought to replicate the results in a large genome-wide association study meta-analysis of ischaemic stroke (study B; N = 3548 cases, 5972 controls).

RESULTS: In study A, the prevalence of hypertension, diabetes and >50% carotid stenosis as well as the levels of LDL cholesterol differed significantly between cases and controls. In a logistic regression model adjusted for the significant covariates, rs676210 associated with CVD events (p = 0.030; odds ratio = 1.29 [95% confidence interval 1.03‒1.63] for risk allele G). In study B, rs676210 did not associate with the history of ischaemic stroke.

CONCLUSIONS: The oxLDL levels increasing variant rs676210 associates with CVD events in patients undergoing coronary angiography.

Original languageEnglish
Pages (from-to)214-7
Number of pages4
JournalAtherosclerosis
Volume234
Issue number1
DOIs
Publication statusPublished - May 2014

Keywords

  • Brain Ischemia
  • Cerebrovascular Disorders
  • Female
  • Humans
  • Lipoproteins, LDL
  • Male
  • Polymorphism, Single Nucleotide
  • Stroke

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