Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme

HALCyon study team; Tamuno Alfred; Yoav Ben-Shlomo; Rachel Cooper; Rebecca Hardy; Ian J Deary; Jane Elliott; Sarah E Harris; Mika Kivimaki; Meena Kumari; Chris Power; John M Starr; Diana Kuh; Ian N M Day

doi:10.1371/journal.pone.0070045

Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme

HALCyon study team, Tamuno Alfred, Yoav Ben-Shlomo, Rachel Cooper, Rebecca Hardy, Ian J Deary, Jane Elliott, Sarah E Harris, Mika Kivimaki, Meena Kumari, Chris Power, John M Starr, Diana Kuh, Ian N M Day

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoproteins. However, associations between SNPs in the gene and other ageing phenotypes such as cognitive and physical capability have not been reported.

Original language	English
Pages (from-to)	e70045
Journal	PLoS ONE
Volume	8
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0070045
Publication status	Published - 23 Jul 2013

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10.1371/journal.pone.0070045

Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypesFinal published version, 174 KB

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0070045

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
A Life course approach to healthy ageing: Capitalising on the value of UK course cohorts
Deary, I.
MRC
1/09/08 → 31/03/13
Project: Research
MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Deary, I., Holmes, M., Logie, P., McCulloch, J., Porteous, D., Roberts, N., Seckl, J., Starr, J. & Wardlaw, J.
MRC
1/09/08 → 31/08/13
Project: Research

Cite this

HALCyon study team, Alfred, T., Ben-Shlomo, Y., Cooper, R., Hardy, R., Deary, I. J., Elliott, J., Harris, S. E., Kivimaki, M., Kumari, M., Power, C., Starr, J. M., Kuh, D., & Day, I. N. M. (2013). Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme. PLoS ONE, 8(7), e70045. https://doi.org/10.1371/journal.pone.0070045

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abstract = "The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoproteins. However, associations between SNPs in the gene and other ageing phenotypes such as cognitive and physical capability have not been reported.",

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AU - Elliott, Jane

AU - Harris, Sarah E

AU - Kivimaki, Mika

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AU - Day, Ian N M

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AB - The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoproteins. However, associations between SNPs in the gene and other ageing phenotypes such as cognitive and physical capability have not been reported.

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Associations between a polymorphism in the pleiotropic GCKR and Age-related phenotypes: the HALCyon programme

Abstract / Description of output

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Projects

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

A Life course approach to healthy ageing: Capitalising on the value of UK course cohorts

MRC Centre for Cognitive Ageing and Cognitive Epidemiology

Cite this