Associations of acute phase protein levels with growth performance and with selection for growth performance in Large White pigs

M Clapperton*, SC Bishop, ND Cameron, EJ Glass

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Acute phase proteins (APP) are released into the circulation in mammals upon infection and may be used to diagnose the health status of managed populations of animals such as pigs. The current study determines APP levels in a population of apparently healthy Large White pigs from a single farm, to address two questions : (1) whether phenotypic associations can be observed between productivity and APP, indicating the effects of possible subclinical infections and (2) whether previous selection for either food intake or `lean growth under restricted feeding' influences APP levels. The APP investigated were alpha(1)-acid glycoprotein (AGP) and haptoglobin. The APP were measured at 18 and 24 weeks of age in pigs previously selected for high lean growth (no. = 31), low lean growth (no. = 38), high daily food intake (no. = 24) and low daily food intake (no. = 26), but performing under ad libitum feeding conditions. Performance traits and APP levels were constant over the experimental period, indicating that the farm health status did not vary over time. Performance traits and APP were recorded on 119 pigs, of which 80 had both APP and performance measurements. Multiple regression analyses were used to investigate phenotypic relationships between performance traits and APP levels. Plasma concentrations of AGP were higher in 18-week- old pigs compared with 24-week- old pigs (P

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalAnimal science
Publication statusPublished - Oct 2005

Keywords / Materials (for Non-textual outputs)

  • haptoglobins
  • genotypes
  • glycoproteins
  • Large White
  • pigs
  • productivity
  • Inflammation
  • Acute Phase Protein


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