TY - JOUR
T1 - Associations with Corneal Hysteresis in a Population Cohort Results from 96 010 UK Biobank Participants
AU - UKBiobank Eye Vision Consortium
AU - Zhang, Bing
AU - Shweikh, Yusrah
AU - Khawaja, Anthony P.
AU - Gallacher, John
AU - Bauermeister, Sarah
AU - Foster, Paul
AU - Aslam, Tariq
AU - Barman, Sarah A.
AU - Barrett, Jenny H.
AU - Bishop, Paul
AU - Blows, Peter
AU - Bunce, Catey
AU - Carare, Roxana O.
AU - Chakravarthy, Usha
AU - Chan, Michelle
AU - Chua, Sharon Y. L.
AU - Crabb, David P.
AU - Cumberland, Philippa M.
AU - Day, Alexander
AU - Desai, Parul
AU - Dhillon, Bal
AU - Dick, Andrew D.
AU - Egan, Cathy
AU - Ennis, Sarah
AU - Foster, Paul
AU - Fruttiger, Marcus
AU - Gallacher, John E. J.
AU - Garway-Heath, David F.
AU - Gibson, Jane
AU - Gore, Dan
AU - Guggenheim, Jeremy A.
AU - Hammond, Chris J.
AU - Hardcastle, Alison
AU - Harding, Simon P.
AU - Hogg, Ruth E.
AU - Hysi, Pirro
AU - Keane, Pearse A.
AU - Khaw, Sir Peng T.
AU - dos Lascaratos, Gerassim
AU - Lotery, Andrew J.
AU - Macgillivray, Tom
AU - Mackie, Sarah
AU - Martin, Keith
AU - McGaughey, Michelle
AU - McGuinness, Bernadette
AU - McKay, Gareth J.
AU - McKibbin, Martin
AU - Mitry, Danny
AU - O'Sullivan, Eoin
AU - Vitart, Veronique
PY - 2019/11
Y1 - 2019/11
N2 - Purpose: To describe the distribution of corneal hysteresis (CH) in a large cohort and explore its associated factors and possible clinical applications.Design: Cross-sectional study within the UK Biobank, a large cohort study in the United Kingdom.Participants: We analyzed CH data from 93 345 eligible participants in the UK Biobank cohort, aged 40 to 69 years.Methods: All analyses were performed using left eye data. Linear regression models were used to evaluate associations between CH and demographic, lifestyle, ocular, and systemic variables. Piecewise logistic regression models were used to explore the relationship between self-reported glaucoma and CH.Main Outcome Measures: Corneal hysteresis (mmHg).Results: The mean CH was 10.6 mmHg (10.4 mmHg in male and 10.8 mmHg in female participants). After adjusting for covariables, CH was significantly negatively associated with male sex, age, black ethnicity, self-reported glaucoma, diastolic blood pressure, and height. Corneal hysteresis was significantly positively associated with smoking, hyperopia, diabetes, systemic lupus erythematosus (SLE), greater deprivation (Townsend index), and Goldmann-correlated intraocular pressure (IOPg). Self-reported glaucoma and CH were significantly associated when CH was less than 10.1 mmHg (odds ratio, 0.86; 95% confidence interval, 0.79-0.94 per mmHg CH increase) after adjusting for covariables. When CH exceeded 10.1 mmHg, there was no significant association between CH and self-reported glaucoma.Conclusions: In our analyses, CH was significantly associated with factors including age, sex, and ethnicity, which should be taken into account when interpreting CH values. In our cohort, lower CH was significantly associated with a higher prevalence of self-reported glaucoma when CH was less than 10.1 mmHg. Corneal hysteresis may serve as a biomarker aiding glaucoma case detection. Crown Copyright (C) 2019 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology
AB - Purpose: To describe the distribution of corneal hysteresis (CH) in a large cohort and explore its associated factors and possible clinical applications.Design: Cross-sectional study within the UK Biobank, a large cohort study in the United Kingdom.Participants: We analyzed CH data from 93 345 eligible participants in the UK Biobank cohort, aged 40 to 69 years.Methods: All analyses were performed using left eye data. Linear regression models were used to evaluate associations between CH and demographic, lifestyle, ocular, and systemic variables. Piecewise logistic regression models were used to explore the relationship between self-reported glaucoma and CH.Main Outcome Measures: Corneal hysteresis (mmHg).Results: The mean CH was 10.6 mmHg (10.4 mmHg in male and 10.8 mmHg in female participants). After adjusting for covariables, CH was significantly negatively associated with male sex, age, black ethnicity, self-reported glaucoma, diastolic blood pressure, and height. Corneal hysteresis was significantly positively associated with smoking, hyperopia, diabetes, systemic lupus erythematosus (SLE), greater deprivation (Townsend index), and Goldmann-correlated intraocular pressure (IOPg). Self-reported glaucoma and CH were significantly associated when CH was less than 10.1 mmHg (odds ratio, 0.86; 95% confidence interval, 0.79-0.94 per mmHg CH increase) after adjusting for covariables. When CH exceeded 10.1 mmHg, there was no significant association between CH and self-reported glaucoma.Conclusions: In our analyses, CH was significantly associated with factors including age, sex, and ethnicity, which should be taken into account when interpreting CH values. In our cohort, lower CH was significantly associated with a higher prevalence of self-reported glaucoma when CH was less than 10.1 mmHg. Corneal hysteresis may serve as a biomarker aiding glaucoma case detection. Crown Copyright (C) 2019 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology
KW - OCULAR HYPERTENSION TREATMENT
KW - COLLAGEN CROSS-LINKING
KW - BIOMECHANICAL PROPERTIES
KW - INTRAOCULAR-PRESSURE
KW - DIABETES-MELLITUS
KW - DIURNAL-VARIATIONS
KW - THICKNESS
KW - GLAUCOMA
KW - PARAMETERS
KW - SMOKING
U2 - 10.1016/j.ophtha.2019.06.029
DO - 10.1016/j.ophtha.2019.06.029
M3 - Article
VL - 126
SP - 1500
EP - 1510
JO - Ophthalmology
JF - Ophthalmology
SN - 0161-6420
IS - 11
ER -